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Current Standards and Limits in Treatment of Hepatic Metastases

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Progress in Regional Cancer Therapy
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Abstract

Hepatic metastases represent a common site of dissemination for a number of primary malignancies, partly because of the dual blood supply, the large blood flow, and the receptive environment of the hepatic parenchyma. Primary gastrointestinal neoplasms are particularly prone to develop hepatic metastases. Most of what we have learned concerns the treatment of metastases of colorectal cancers, because these primary lesions are very common, usually can be removed widely along with regional lymphatic spread, and thus often give rise to resectable hepatic metastases that appear to be the only residual sites of growth.

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References

  1. Wood CB, Gillis CR, Blumgart LH (1976) A retrospective study of the natural history of patients with liver metastases from colorectal cancer. Clin Oncol 2:285–288

    PubMed  CAS  Google Scholar 

  2. Bismuth H (1982) Surgical anatomy and anatomical surgery of the liver. World J Surg 6:3–9

    Article  PubMed  CAS  Google Scholar 

  3. Adson MA (1987) Resection of liver metastases—when is it worthwhile? World J Surg 11:511–520

    Article  PubMed  CAS  Google Scholar 

  4. Foster JH (1978) Survival after liver resection for secondary tumors. Am J Surg 135:389–394

    Article  PubMed  CAS  Google Scholar 

  5. Logan SE, Meier SJ, Ramming KP, Morton DL, Longmire WP Jr (1982) Hepatic resection of metastases colorectal carcinoma: a ten year experience. Arch Surg 117:25–28

    PubMed  CAS  Google Scholar 

  6. Kortz WJ, Meyers WC, Hanks JB et al. (1984) Hepatic resection for metastatic cancer. Ann Surg 199:182–186

    Article  PubMed  CAS  Google Scholar 

  7. Fortner JG, Silva JS, Golbey RB, Cox EB, Maclean BJ (1984) Multivariate analysis of a personal series of 247 consecutive patients with liver metastases from colorectal cancer. Ann Surg 199:306–316

    Article  PubMed  CAS  Google Scholar 

  8. Butler J, Attiyeh FF, Daly JM (1986) Hepatic resection for metastases of the colon and rectum. Surg Gynecol Obstet 162:109–113

    PubMed  CAS  Google Scholar 

  9. Cady B, Oberfield RA (1974) Regional infusion chemotherapy of hepatic metastases from carcinoma of the colon. Am J Surg 127:220–227

    Article  PubMed  CAS  Google Scholar 

  10. Ekberg H (1986) Colorectal liver cancer, resection and regional chemotherapy. Thesis. Bulletin no. 61, Department of Surgery, Lund University, Lund, Sweden pp 1–62

    Google Scholar 

  11. Iwatsuki S, Byers W, Starzl TE (1983) Experience with 150 liver resections. Ann Surg 197:247–253

    Article  PubMed  CAS  Google Scholar 

  12. Kemeny N (1983) The systemic chemotherapy of hepatic metastases. Semin Oncol 10:148–158

    PubMed  CAS  Google Scholar 

  13. Balch CM, Urist MM (1983) Vollständig implantierbare Infusions-pumpe. Eine neue Behandlungsmöglichkeit für ausgewählte Patienten mit Lebertumoren. Dtsch med Wochenschr 26:1008–1013

    Article  Google Scholar 

  14. Ensminger W, Niederhuber J, Dakhil S, Thrall J, Wheeler R (1981) Totally implanted drug delivery system for hepatic arterial chemotherapy. Cancer Treat Rep 65:393–400

    PubMed  CAS  Google Scholar 

  15. Niederhuber JE, Ensminger W, Gyves J, Thrall J, Walker S, Cozzi E (1984) Regional chemotherapy of colorectal cancer metastatic to the liver. Cancer 53:1336–1343

    Article  PubMed  CAS  Google Scholar 

  16. Barone RM, Byfield JE, Goldfarb PB, Frankel S, Ginn S, Greer S (1982) Intraarterial chemotherapy using an implantable infusion pump and liver irradiation for the treatment of hepatic metastases. Cancer 50:850–862

    Article  PubMed  CAS  Google Scholar 

  17. Cohen AM, Kaufman SD, Wood WC, Greenfield AJ (1983) Regional hepatic chemotherapy using an implantable drug infusion pump. Am J Surg 145:529–533

    Article  PubMed  CAS  Google Scholar 

  18. Balch CM, Urist MM, Soong SJ, McGregor M (1983) A prospective phase II clinical trial of continuous FUDR regional chemotherapy for colorectal metastases to the liver using a totally implantable drug infusion pump. Ann Surg 198:567–573

    Article  PubMed  CAS  Google Scholar 

  19. Balch CM, Urist MM (1986) Intraarterial chemotherapy for colorectal liver metastases and hepatomas using a totally implantable drug infusion pump. In: Recent Results Cancer Res 100:234–247

    PubMed  CAS  Google Scholar 

  20. Daly JM, Kemeny N, Oderman P, Botet J (1984) Long-term hepatic arterial infusion chemotherapy: anatomic considerations, operative technique and treatment morbidity. Arch Surg 119:936–941

    PubMed  CAS  Google Scholar 

  21. Shepard KV, Levin B, Karl RC, Faintuch J, DuBrow RA, Hagle M et al. (1985) Therapy for metastatic colorectal cancer with hepatic artery infusion chemotherapy using subcutaneous implanted pump. J Clin Oncol 3:161–169

    PubMed  CAS  Google Scholar 

  22. Kemeny N, Reichman B, Oderman P, Daly J, Geller N (1986) Update of randomized study of intrahepatic (H) vs systemic (S) infusion of fluorodeoxyuridine (FUDR) in patients with liver metastases from colorectal carcinoma (CRC). Proc Am Soc Clin Oncol 5:47

    Google Scholar 

  23. Patt YZ, Boddie AW, Charnsangavej C, Ajani JA, Wallace S, Soski M et al. (1986) Hepatic arterial infusion with fluoxuridine and cisplatin: overriding importance of antitumor effect versus degree of tumor burden as determinants of survival among patients with colorectal cancer. J Clin Oncol 4:1356–1364

    PubMed  CAS  Google Scholar 

  24. Hottenrott C, Lorenz M (1987) Stellenwert der regionalen Chemotherapie der Leber. Z Gastroenterol 25:364–373

    PubMed  CAS  Google Scholar 

  25. Wagner JS, Adson MA, van Heerden JA, Adson MH, Ilstrup DM (1984) The natural history of hepatic metastases from celorectal cancer. A comparison with resective treatment Ann Surg 199:502–508

    CAS  Google Scholar 

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© 1990 Springer-Verlag Berlin Heidelberg

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Bittner, R., Safi, F., Link, K.H., Beger, H.G. (1990). Current Standards and Limits in Treatment of Hepatic Metastases. In: Jakesz, R., Rainer, H. (eds) Progress in Regional Cancer Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74818-9_15

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  • DOI: https://doi.org/10.1007/978-3-642-74818-9_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74820-2

  • Online ISBN: 978-3-642-74818-9

  • eBook Packages: Springer Book Archive

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