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The Pathogenic Role of Human Immunodeficiency Virus Accessory Genes in Transgenic Mice

  • Chapter
Transacting Functions of Human Retroviruses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 193))

Abstract

Human immunodeficiency virus (HIV) type 1, the causative agent of acquired immune deficiency syndrome (AIDS), was isolated almost a decade ago (Barré-Sinoussi et al. 1983; Popovic et al. 1984). HIV infection is mediated by the binding of the virus to the CD4 cell surface molecule and subsequent viral penetration (Dalgleish et al. 1984; Klatzmann et al. 1984; McDougal et al. 1986). Cells known to bear CD4 include the T-helper/inducer cells (Terhorst et al. 1980), immature thymocytes (Schnittman et al. 1990), Epstein-Barr virus (EBV)+ B lymphoblastoid cells (Dalgleish et al. 1984; Salahuddin et al. 1987; Monroe et al. 1988), monocytes/macrophages (Wood et al. 1983; Dalgleish et al. 1984), follicular dendritic cells (Wood et al. 1983; Macatonia et al. 1990), Langerhans cells (Wood et al. 1983; Tschachler et al. 1987), astrocytes (Funke et al. 1987), neurons (Funke et al. 1987), and glomerular mesangial cells (KARLSSON-PARRA et al. 1989).

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Authors and Affiliations

  1. Department of Virology, Jerome H. Holland Laboratory, American Red Cross, Rockville, MD, 20855, USA

    B. T. Tinkle, H. Ueda & G. Jay

  2. Graduate Program in Genetics, George Washington University, Washington, DC, 20052, USA

    G. Jay

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  1. B. T. Tinkle
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  2. H. Ueda
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  3. G. Jay
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Editors and Affiliations

  1. Division of Hematology/Oncology, 11-934 Factor, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA, 90024-1678, USA

    Irvin S. Y. Chen

  2. Department of Microbiology and Immunology Head of the Center of Neurovirology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA, 10107, USA

    Hilary Koprowski

  3. Department of Microbiology/Immunology Center for Neurovirology, Jefferson Medical College, Rm. 469 Jefferson Alumni Hall 1020 Locust Street, Philadelphia, PA, 19107-6799, USA

    Alagarsamy Srinivasan

  4. The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Peter K. Vogt

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© 1995 Springer-Verlag Berlin Heidelberg

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Tinkle, B.T., Ueda, H., Jay, G. (1995). The Pathogenic Role of Human Immunodeficiency Virus Accessory Genes in Transgenic Mice. In: Chen, I.S.Y., Koprowski, H., Srinivasan, A., Vogt, P.K. (eds) Transacting Functions of Human Retroviruses. Current Topics in Microbiology and Immunology, vol 193. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78929-8_8

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  • DOI: https://doi.org/10.1007/978-3-642-78929-8_8

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