Zusammenfassung
Indikationen, Wirkungsweise, Nebenwirkungen und Risiken, Kontraindikationen und Interaktionen werden einmal im allgemeinen Teil und dann für jedes Antidepressivum spezifisch im Präparateteil beschrieben. Jedes Präparat wird bewertet. In einem eigenen Abschnitt werden die Unterschiede der Antidepressiva in Bezug auf Wirksamkeit und Nebenwirkungen analysiert. Alle Indikationen für Antidepressiva, von den depressiven Störungen über die Angst- und Zwangsstörungen bis zu den Trauma- und belastungsbezogenen Störungen, werden abgehandelt. Der Schwerpunkt liegt auch in dieser Auflage im praktischen Umgang mit Antidepressiva.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Literatur
Aan het Rot M, Zarate CA Jr, Charney DS, Mathew SJ (2012) Ketamine for depression: where do we go from here? Biol Psychiatry 72(7): 537–547
Anderson IM, Blamire A, Branton T et al; Ketamine-ECT Study Team (2017) Ketamine augmentation of electroconvulsive therapy to improve neuropsychological and clinical outcomes in depression (Ketamine-ECT): a multicentre, double-blind, randomised, parallel-group, superiority trial. Lancet Psychiatry 4(5): 365–377
Andrews G, Basu A, Cuijpers P et al (2018) Computer therapy for the anxiety and depression disorders is effective, acceptable and practical health care: an updated meta-analysis. J Anxiety Disord pii: S0887–6185(17)30447-4
Bartels C, Wagner M, Wolfsgruber S et al; Alzheimer’s Disease Neuroimaging Initiative (2018) Impact of SSRI therapy on risk of conversion from mild cognitive impairment to Alzheimer’s dementia in individuals with previous depression. Am J Psychiatry 175(3): 232–241
Batelaan NM, Bosman RC, Muntingh A et al (2017) Risk of relapse after antidepressant discontinuation in anxiety disorders, obsessive-compulsive disorder, and post-traumatic stress disorder: systematic review and meta-analysis of relapse prevention trials. BMJ 358: j3927
Boland EM, Rao H, Dinges DF et al (2017) Meta-analysis of the antidepressant effects of acute sleep deprivation. J Clin Psychiatry 78(8): e1020–e1034
Brouwer A, Nguyen HT, Snoek FJ et al (2017) Light therapy: is it safe for the eyes? Acta Psychiatr Scand 136(6): 534–548
Brunet A, Saumier D, Liu A et al (2018) Reduction of PTSD symptoms with pre-reactivation propranolol therapy: a randomized controlled trial. Am J Psychiatry 175(5): 427–433
Brunoni AR, Moffa AH, Sampaio-Junior B et al; ELECT-TDCS Investigators (2017) Trial of electrical direct-current therapy versus escitalopram for depression. N Engl J Med 376(26): 2523–2533
Bykov K, Schneeweiss S, Donneyong MM et al (2017) Impact of an interaction between clopidogrel and selective serotonin reuptake inhibitors. Am J Cardiol 119(4): 651–657
Chen HY, Lin CL, Lai SW, Kao CH (2016) Association of selective serotonin reuptake inhibitor use and acute angle-closure glaucoma. J Clin Psychiatry 77(6): e692–696
Chou PH, Chu CS, Chen YH et al (2017) Antidepressants and risk of cataract development: a population-based, nested case-control study. J Affect Disord 215 : 237–244
Cipriani A, Furukawa TA, Salanti G et al (2018) Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. Lancet 391(10128): 1357–1366
Daly EJ, Singh JB, Fedgchin M et al (2018) Efficacy and safety of intranasal esketamine adjunctive to oral antidepressant therapy in treatment-resistant depression: a randomized clinical trial. JAMA Psychiatry 75(2): 139–148
DGPPN, BÄK, KBV, AWMF, AkdÄ, BPtK, BApK, DAGSHG, DEGAM, DGPM, DGPs, DGRW (Hrsg) für die Leitliniengruppe Unipolare Depression (2015) S3-Leitlinie/Nationale VersorgungsLeitlinie Unipolare Depression – Langfassung, 2. Aufl. Version 5 ( https://www.leitlinien.de/nvl/depression , Online-Zugriff: 11.03.2018)
Dougherty DD, Rezai AR, Carpenter LL et al (2015) A randomized sham-controlled trial of deep brain stimulation of the ventral capsule/ventral striatum for chronic treatment-resistant depression. Biol Psychiatry 78(4): 240–248
Driessen E, Hollon SD, Bockting CL et al (2015) Does publication bias inflate the apparent efficacy of psychological treatment for major depressive disorder? A systematic review and meta-analysis of US National Institutes of Health-funded trials. PLoS One 10(9): e0137864
Fava M, Memisoglu A, Thase ME et al (2016) Opioid modulation with buprenorphine/samidorphan as adjunctive treatment for inadequate response to antidepressants: a randomized double-blind placebo-controlled trial. Am J Psychiatry 173(5): 499–508
Fernie G, Currie J, Perrin JS et al (2017) Ketamine as the anaesthetic for electroconvulsive therapy: the KANECT randomised controlled trial. Br J Psychiatry 210(6): 422–428
Finnerup NB, Attal N, Haroutounian S et al (2015) Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol 14(2): 162–173
Fu Y, Dai Q, Zhu L, Wu S (2018) Antidepressants use and risk of cataract development: a systematic review and meta-analysis. BMC Ophthalmol 18(1): 31
Furukawa TA, Cipriani A, Atkinson LZ et al (2016) Placebo response rates in antidepressant trials: a systematic review of published and unpublished double-blind randomised controlled studies. Lancet Psychiatry 3(11): 1059–1066
Grunebaum MF, Galfalvy HC, Choo TH et al (2018) Ketamine for rapid reduction of suicidal thoughts in major depression: a midazolam-controlled randomized clinical trial. Am J Psychiatry 175(4): 327–335
Guidi J, Tomba E, Fava GA (2016) The sequential integration of pharmacotherapy and psychotherapy in the treatment of major depressive disorder: a meta-analysis of the sequential model and a critical review of the literature. Am J Psych 173(2): 128–137
Hiemke C, Bergemann N, Clement HW et al (2018) Consensus guidelines for therapeutic drug monitoring in neuropsychopharmacology: update 2017. Pharmacopsychiatry 51(1-02): 9–62
Hieronymus F, Emilsson JF, Nilsson S, Eriksson E (2016) Consistent superiority of selective serotonin reuptake inhibitors over placebo in reducing depressed mood in patients with major depression. Mol Psychiatry 21(4): 523–530
Jakubovski E, Varigonda AL, Freemantle N et al (2016) Systematic review and meta-analysis: dose-response relationship of selective serotonin reuptake inhibitors in major depressive disorder. Am J Psychiatry 173(2): 174–183
Kanes S, Colquhoun H, Gunduz-Bruce H et al (2017) Brexanolone (SAGE-547 injection) in post-partum depression: a randomised controlled trial. Lancet 390(10093): 480–489
Karyotaki E, Riper H, Twisk J et al (2017) Efficacy of self-guided internet-based cognitive behavioral therapy in the treatment of depressive symptoms: a meta-analysis of individual participant data. JAMA Psychiatry 74(4): 351–359
Katon W, Pedersen HS, Ribe AR et al (2015) Effect of depression and diabetes mellitus on the risk for dementia: a national population-based cohort study. JAMA Psychiatry 72(6): 612–619
Khan A, Fahl Mar K, Faucett J et al (2017) Has the rising placebo response impacted antidepressant clinical trial outcome? Data from the US Food and Drug Administration 1987–2013. World Psychiatry 16(2): 181–192
Kiosses DN, Ravdin LD, Gross JJ et al (2015) Problem adaptation therapy for older adults with major depression and cognitive impairment: a randomized clinical trial. JAMA Psychiatry 72(1): 22–30
Kupfer DJ (1991) Long-term treatment of depression. J Clin Psychiatry 52(Suppl 5): 28–34
Kuyken W, Warren FC, Taylor RS et al (2016) Efficacy of mindfulness-based cognitive therapy in prevention of depressive relapse: an individual patient data meta-analysis from randomized trials. JAMA Psychiatry 73(6): 565–574
Lazarov A, Pine DS, Bar-Haim Y (2017) Gaze-contingent music reward therapy for social anxiety disorder: a randomized controlled trial. Am J Psychiatry 174(7): 649–656
Mataix-Cols D, Fernández de la Cruz L, Monzani B et al; and the DCS Anxiety Consortium, Altemus M, Anderson P, Cukor J et al (2017) D-Cycloserine augmentation of exposure-based cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders: a systematic review and meta-analysis of individual participant data. JAMA Psychiatry 74(5): 501–510
McAllister-Williams RH, Anderson IM et al (2016) Antidepressant augmentation with metyrapone for treatment-resistant depression (the ADD study): a double-blind, randomised, placebo-controlled trial. Lancet Psychiatry 3(2): 117–127
McClintock SM, Reti IM, Carpenter LL et al; National Network of Depression Centers rTMS Task Group; American Psychiatric Association Council on Research Task Force on Novel Biomarkers and Treatments (2018) Consensus recommendations for the clinical application of repetitive transcranial magnetic stimulation (rTMS) in the treatment of depression. J Clin Psychiatry 79(1). pii: 16cs10905
Mead GE, Hsieh CF, Lee R et al (2013) Selective serotonin reuptake inhibitors for stroke recovery: a systematic review and meta-analysis. Stroke 44(3): 844–850
Meister R, Jansen A, Berger M et al (2018) Psychotherapie depressiver Störungen. Verfahren, Evidenz und Perspektiven. Nervenarzt 89(3): 241–251
Orgeta V, Tabet N, Nilforooshan R, Howard R (2017) Efficacy of antidepressants for depression in Alzheimer’s disease: systematic review and meta-analysis. J Alzheimers Dis 58(3): 725–733
Orlova Y, Rizzoli P, Loder E (2018) Association of coprescription of triptan antimigraine drugs and selective serotonin reuptake inhibitor or selective norepinephrine reuptake inhibitor antidepressants with serotonin syndrome. JAMA Neurol 75(5): 566–572
Paulzen M, Haen E, Hiemke C et al (2018) Antidepressant polypharmacy and the potential of pharmacokinetic interactions: Doxepin but not mirtazapine causes clinically relevant changes in venlafaxine metabolism. J Affect Disord 227: 506–511
Renoux C, Vahey S, Dell’Aniello S, Boivin JF (2017) Association of selective serotonin reuptake inhibitors with the risk for spontaneous intracranial hemorrhage. JAMA Neurol 74(2): 173–180
Rohan KJ, Meyerhoff J, Ho SY et al (2016) Outcomes one and two winters following cognitive-behavioral therapy or light therapy for seasonal affective disorder. Am J Psychiatry 173(3): 244–251
Salagre E, Fernandes BS, Dodd S et al (2016) Statins for the treatment of depression: a meta-analysis of randomized, double-blind, placebo-controlled trials. J Affect Disord 200: 235–242
Sanacora G, Frye MA, McDonald W et al; American Psychiatric Association (APA) Council of Research Task Force on Novel Biomarkers and Treatments (2017) A consensus statement on the use of ketamine in the treatment of mood disorders. JAMA Psychiatry 74(4): 399–405
Schramm E, Kriston L, Zobel I et al (2017) Effect of disorder-specific vs nonspecific psychotherapy for chronic depression: a randomized clinical trial. JAMA Psychiatry 74(3): 233–242
Sharma T, Guski LS, Freund N, Gøtzsche PC (2016) Suicidality and aggression during antidepressant treatment: systematic review and meta-analyses based on clinical study reports. BMJ 352: i65
Sit DK, McGowan J, Wiltrout C et al (2018) Adjunctive bright light therapy for bipolar depression: a randomized double-blind placebo-controlled trial. Am J Psychiatry 175(2): 131–139
Stingl JC, Brockmöller J (2013) Personalisierte Pharmakotherapie. Evidenzbasierte Leitlinien und klinische Anwendung pharmakogenetischer Diagnostik. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 56(11): 1509–1521
Taylor JH, Landeros-Weisenberger A et al (2018) Ketamine for social anxiety disorder: a randomized, placebo-controlled crossover trial. Neuropsychopharmacology 43(2): 325–333
Torvinen-Kiiskinen S, Tolppanen AM, Koponen M et al (2017) Antidepressant use and risk of hip fractures among community-dwelling persons with and without Alzheimer’s disease. Int J Geriatr Psychiatry 32(12): e107–e115
Undurraga J, Baldessarini RJ (2017) Direct comparison of tricyclic and serotonin-reuptake inhibitor antidepressants in randomized head-to-head trials in acute major depression: Systematic review and meta-analysis. J Psychopharmacol 31(9): 1184–1189
Voican CS, Corruble E, Naveau S, Perlemuter G (2014) Antidepressant-Induced Liver Injury: A Review for Clinicians. Am J Psychiatry 171(4): 404–415
Wenzel-Seifert K, Wittmann M, Haen E (2011) QTc prolongation by psychotropic drugs and the risk of Torsades de Pointes. Dtsch Arztebl Int 108(41): 687–693
WHO (World Health Organization and United Nations High Commissioner for Refugees) (2013) Assessment and Management of Conditions Specifically Related to Stress: mhGAP Intervention Guide Module (version 1.0). Geneva
Wilkinson ST, Ballard ED, Bloch MH et al (2018) The effect of a single dose of intravenous ketamine on suicidal ideation: a systematic review and individual participant data meta-analysis. Am J Psychiatry 175(2): 150–158
Zhou X, Ravindran AV, Qin B et al (2015) Comparative efficacy, acceptability, and tolerability of augmentation agents in treatment-resistant depression: systematic review and network meta-analysis. J Clin Psychiatry 76(4): e487–98
Author information
Authors and Affiliations
Corresponding authors
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer-Verlag GmbH Deutschland
About this chapter
Cite this chapter
Regen, F., Benkert, O. (2019). Antidepressiva. In: Benkert, O., Hippius, H. (eds) Kompendium der Psychiatrischen Pharmakotherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-57334-1_1
Download citation
DOI: https://doi.org/10.1007/978-3-662-57334-1_1
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-57333-4
Online ISBN: 978-3-662-57334-1
eBook Packages: Medicine (German Language)