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Nitric Oxide Contributes to Retinal Ganglion Cell Survival Through Protein S-Nitrosylation After Optic Nerve Injury

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Neuroprotection and Neuroregeneration for Retinal Diseases

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Abstract

Neuroprotective strategies to attenuate retinal ganglion cell (RGC) death could lead to novel therapies for chronic optic neuropathies such as glaucoma. Nitric oxide (NO) signaling results in both neurotoxic and neuroprotective effects in CNS neurons after nerve lesion. However, the functional mechanisms of NO in the nervous system are not fully understood. Protein S-nitrosylation by NO is a posttranslational modification that regulates protein function through the reaction of NO with a cysteine thiol group on target proteins. NO/S-nitrosylation is now thought to be important in regulating cell death, survival, and gene expression. However, there are few reports on the role of protein S-nitrosylation in glaucoma. Therefore, we investigated the role of protein S-nitrosylation signaling in RGC survival after optic nerve injury.

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Authors and Affiliations

  1. Department of Molecular Neurobiology, Graduate School of Medicine, Kanazawa University, 13-1 Takaramachi, Kanazawa, 920-8640, Japan

    Yoshiki Koriyama & Satoru Kato

  2. Graduate School and Faculty of Pharmaceutical Sciences, Suzuka University of Medical Sciences, 3500-3 Minamitamagaki, Suzuka, 513-8670, Japan

    Yoshiki Koriyama & Satoru Kato

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  1. Yoshiki Koriyama
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  2. Satoru Kato
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Correspondence to Yoshiki Koriyama .

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Editors and Affiliations

  1. Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan

    Toru Nakazawa

  2. Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, Japan

    Yasushi Kitaoka

  3. Visual Research Project, Tokyo Metropolitan Inst of Med Sci, Tokyo, Japan

    Takayuki Harada

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Koriyama, Y., Kato, S. (2014). Nitric Oxide Contributes to Retinal Ganglion Cell Survival Through Protein S-Nitrosylation After Optic Nerve Injury. In: Nakazawa, T., Kitaoka, Y., Harada, T. (eds) Neuroprotection and Neuroregeneration for Retinal Diseases. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54965-9_6

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