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Abstract

In this chapter, we define N-of-1 trials and provide a brief historical perspective. We briefly cover the background and rationale for N-of-1 trials, and discuss their benefits.

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References

  • Askew DA (2005). A study of research adequacy in Australian general practice. PhD thesis, The University of Queensland, Brisbane

    Google Scholar 

  • Australian Council for Safety and Quality in Health Care (2006) National inpatient medication chart: general instructions/information for doctors. The Australian Department of Health and Ageing, Canberra

    Google Scholar 

  • Centers for Chronic Disease Prevention and Health Promotion (2009) The power of prevention chronic disease….the public health challenge of the 21st century. http://www.cdc.gov/chronicdisease/pdf/2009-power-of-prevention.pdf. Accessed 31 Oct 2014

  • Commonwealth Department of Human Services and Health (2009) A policy on the quality use of medicines. Commonwealth Department of Human Services and Health, Canberra

    Google Scholar 

  • Curry LC, Walker C, Hogstel MO, Burns P (2005) Teaching older adults to self manage medications: preventing adverse drug reactions. J Gerontol Nurs 31(4):32–42

    Article  PubMed  Google Scholar 

  • Cushny AR, Peebles AR (1905) The action of optical isomers: II. Hyoscines. J Physiol 32(5–6):501–510

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Facey K, Granados A, Guyatt G, Kent A, Shah N, van der Wilt GJ, Wong-Rieger D (2014) Generating health technology assessment evidence for rare diseases. Int J Technol Assess Health Care 19:1–7 [Epub ahead of print]

    Google Scholar 

  • Gabler NB, Duan N, Vohra S, Kravitz RL (2011) N-of-1 trials in the medical literature: a systematic review. Med Care 49(8):761–768. doi:10.1097/MLR.0b013e318215d90d

    Article  PubMed  Google Scholar 

  • Guyatt G, Sackett D, Taylor DW et al (1986) Determining optimal therapy: randomized trials in individual patients. N Engl J Med 314:889–892

    Article  CAS  PubMed  Google Scholar 

  • Guyatt G, Sackett D, Adachi J et al (1988) A clinician’s guide for conducting randomized trials in individual patients. CMAJ 139:497–503

    PubMed Central  CAS  PubMed  Google Scholar 

  • Guyatt GH et al (2000) Users′ guides to the medical literature: XXV. Evidence‐based medicine: principles for applying the users′ guides to patient care. Evidence‐based medicine working group. JAMA 284(10):1290–1296

    Article  CAS  PubMed  Google Scholar 

  • Jayanthi LD, Ramamoorthy S (2005) Regulation of monoamine transporters: influence of psychostimulants and therapeutic antidepressants. AAPS J 7(3):E728–E738

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Kellner R, Sheffield BF (1968) The use of self-rating scales in a single-patient multiple cross-over trial. Br J Psych 114(507):193–196

    Article  CAS  Google Scholar 

  • Larson EB (1990) N-of-1 clinical trials. A technique for improving medical therapeutics. West J Med 152:52–56

    PubMed Central  CAS  PubMed  Google Scholar 

  • Larson EB, Ellsworth AJ, Oas J (1993) Randomised clinical trials in single patients during a 2–year period. JAMA 270(22):2708–2712

    Article  CAS  PubMed  Google Scholar 

  • Mapel DW, Shainline M, Paez K, Gunter M (2004) Hospital, pharmacy and outpatient costs for osteoarthritis and chronic back pain. J Rheum 31(3):573–583

    PubMed  Google Scholar 

  • Mitchell G, Hardy J, Nikles J, Carmont S, Senior H, Schluter P, Good P, Currow D (2015) The effect of methylphenidate on fatigue in advanced cancer: an aggregated n-of-1 trial. J Pain Symptom Manage. doi:10.1016/j.jpainsymman.2015.03.009

    Google Scholar 

  • Moulding N, Fahy N, Heng Foong L, Yeoh J, Silagy C, Weller D (1997) A systematic review of the current status of evidence-based medicine and its potential application to Australian general practice. A report to the Commonwealth Department of Health and Family Services. Department of General Practice, Flinders University

    Google Scholar 

  • Nikles CJ, Clavarino AM, Del Mar CB (2005) Using N-of-1 trials as a clinical tool to improve prescribing. Br J Gen Pract 55(512):175–180

    PubMed Central  PubMed  Google Scholar 

  • Nikles J, McKinlay L, Mitchell G, Carmont S-A, Senior H, Waugh M-C, Epps A, Schluter P, Lloyd O (2014) Aggregated N-of-1 trials of CNS stimulants versus placebo for paediatric traumatic brain injury – a pilot study. Trials 15:54

    Article  PubMed Central  PubMed  Google Scholar 

  • PBS expenditure and prescriptions, July 2012 to June 2013. Pharmaceutical benefits scheme website. http://www.pbs.gov.au/statistics/2012-2013-files/expenditure-and-prescriptions-12-months-to-30-06-2013.pdf. Accessed 31 Oct 2014

  • Roughead EE, Semple SJ (2009) Medication safety in acute care in Australia: where are we now? Part 1: a review of the extent and causes of medication problems 2002–2008. Australia and New Zealand Health Policy, 6. http://www.anzhealthpolicy.com/content/6/1/18. Accessed 18 Aug 2013

  • Sorensen L, Stokes JA, Purdie DM, Woodward M, Roberts MS (2005) Medication management at home: medication-related risk factors associated with poor health outcomes. Age Ageing 34(6):626–632

    Article  PubMed  Google Scholar 

  • Walker JS, Sheather-Reid RB, Carmody JJ, Vial JH, Day RO (1997) Nonsteroidal anti-inflammatory drugs in rheumatoid arthritis and OA: support for the concept of “responders” and “nonresponders”. Art Rheum s40(11):1944–1954

    Article  Google Scholar 

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Correspondence to Jane Nikles .

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Nikles, J. (2015). What are N-of-1 Trials?. In: Nikles, J., Mitchell, G. (eds) The Essential Guide to N-of-1 Trials in Health. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-7200-6_2

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