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Evolution of Integrin I Domains

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I Domain Integrins

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 819))

Abstract

In humans, an ~200-residue “inserted” I domain, a von Willebrand factor A domain (vWFA), buds out from the β-propeller domain in 9 of 18 integrin α subunits. The vWFA domain is not unique to the α subunit as it is an integral part of all integrin β subunits and many other proteins. The βI domain has always been a component of integrins but the αI domain makes its appearance relatively late, in early chordates, since it is found in tunicates and later diverging species. The tunicate αI domains are distinct from the human collagen and leukocyte recognizing integrin α subunits, but fragments of integrins from agnathastomes suggest that the human-type αI domains arose in an ancestor of the very first vertebrate species. The rise of integrins with αI domains parallels the enormous changes in body plan and systemic development of the chordate line that began some 550 million or more years ago.

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Acknowledgments

We thank the agencies that have contributed funding to our studies on integrins, including the Foundation of Åbo Akademi University (Center of Excellence in Cell Stress and Aging), the Sigrid Juselius Foundation, and the Joe, Pentti and Tor Borg Memorial Fund to MSJ; and the National Doctoral Program in Informational and Structural Biology to BC. We gratefully acknowledge computational resources from the Biocenter Finland bioinformatics infrastructure network (Academy of Finland) and CSC IT Center for Science.

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  1. Structural Bioinformatics Laboratory, Biochemistry, Department of Biosciences, Åbo Akademi University, Tykistökatu 6A, 20520, Turku, Finland

    Mark S. Johnson & Bhanupratap Singh Chouhan

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  1. Mark S. Johnson
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  2. Bhanupratap Singh Chouhan
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Correspondence to Mark S. Johnson .

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  1. University of Bergen, Bergen, Norway

    Donald Gullberg

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Johnson, M.S., Chouhan, B.S. (2014). Evolution of Integrin I Domains. In: Gullberg, D. (eds) I Domain Integrins. Advances in Experimental Medicine and Biology, vol 819. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9153-3_1

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