Scolaris Content Display Scolaris Content Display

Buprenorphine for the management of opioid withdrawal

This is not the most recent version

Collapse all Expand all

Abstract

available in

Background

Managed withdrawal is a necessary step prior to drug‐free treatment or as the end point of substitution treatment.

Objectives

To assess the effectiveness of interventions involving the use of buprenorphine to manage opioid withdrawal, for withdrawal signs and symptoms, completion of withdrawal and adverse effects.

Search methods

We searched the Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 3, 2008), MEDLINE (January 1966 to July 2008), EMBASE (January 1985 to 2008 Week 31), PsycINFO (1967 to 7 August 2008) and reference lists of articles.

Selection criteria

Randomised controlled trials of interventions involving the use of buprenorphine to modify the signs and symptoms of withdrawal in participants who were primarily opioid dependent. Comparison interventions involved reducing doses of methadone, alpha2‐adrenergic agonists, symptomatic medications or placebo, or different buprenorphine‐based regimes.

Data collection and analysis

One author assessed studies for inclusion and methodological quality, and undertook data extraction. Inclusion decisions and the overall process was confirmed by consultation between all authors.

Main results

Twenty‐two studies involving 1736 participants were included. The major comparisons were with methadone (5 studies) and clonidine or lofexidine (12 studies). Five studies compared different rates of buprenorphine dose reduction.

Severity of withdrawal is similar for withdrawal managed with buprenorphine and withdrawal managed with methadone, but withdrawal symptoms may resolve more quickly with buprenorphine. It appears that completion of withdrawal treatment may be more likely with buprenorphine relative to methadone (RR 1.18; 95% CI 0.93 to 1.49, P = 0.18) but more studies are required to confirm this.

Relative to clonidine or lofexidine, buprenorphine is more effective in ameliorating the symptoms of withdrawal, patients treated with buprenorphine stay in treatment for longer (SMD 0.92, 95% CI 0.57 to 1.27, P < 0.001), and are more likely to complete withdrawal treatment (RR 1.64; 95% CI 1.31 to 2.06, P < 0.001). At the same time there is no significant difference in the incidence of adverse effects, but drop‐out due to adverse effects may be more likely with clonidine.

Authors' conclusions

Buprenorphine is more effective than clonidine or lofexidine for the management of opioid withdrawal. Buprenorphine may offer some advantages over methadone, at least in inpatient settings, in terms of quicker resolution of withdrawal symptoms and possibly slightly higher rates of completion of withdrawal.

PICOs

Population
Intervention
Comparison
Outcome

The PICO model is widely used and taught in evidence-based health care as a strategy for formulating questions and search strategies and for characterizing clinical studies or meta-analyses. PICO stands for four different potential components of a clinical question: Patient, Population or Problem; Intervention; Comparison; Outcome.

See more on using PICO in the Cochrane Handbook.

Plain language summary

available in

Buprenorphine is more effective than clonidine or lofexidine, and may have advantages over methadone, for the management of opioid withdrawal.

Dependence on opioid drugs (heroin, methadone) is a major health and social issue in many societies. Managed withdrawal from opioid dependence is an essential first step for drug‐free treatment. This review of trials found that the drug buprenorphine is more effective than clonidine or lofexidine in reducing the signs and symptoms of opioid withdrawal, retaining patients in withdrawal treatment, and supporting the completion of treatment. There is no significant difference in the incidence of adverse effects, but patients treated with buprenorphine may be less likely to drop‐out due to adverse effects than is the case with clonidine or lofexidine. There is limited evidence comparing buprenorphine with methadone, but it appears that completion of withdrawal may be more likely with buprenorphine and withdrawal symptoms may resolve more quickly with buprenorphine.