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Vascular Liver Disease and the Liver Sinusoidal Endothelial Cell

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Vascular Liver Disease

Abstract

The hepatic sinusoidal endothelial cell is highly differentiated, with unique morphology and function. It provides a porous barrier that facilitates access of the hepatocyte to oxygen and small molecules in the microcirculation. Other specialized functions include clearance of colloids and macromolecules, promotion of hepatic stellate cell quiescence, and induction of immune tolerance. The hepatic sinusoidal endothelial cell may be injured by a variety of toxins, ischemia–reperfusion, and even bacteria, leading to vascular liver diseases such as sinusoidal obstruction syndrome, nodular regenerative hyperplasia, and peliosis hepatis.

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  1. Division of Gastrointestinal and Liver Diseases, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue- HMR 603, Los Angeles, CA, 90033, USA

    Laurie D. DeLeve

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  1. Keck School of Medicine, Div. GI & Liver Diseases, University of Southern California, Los Angeles, 90033, California, USA

    Laurie D. DeLeve

  2. , Section of Digestive Diseases, Yale University School of Medicine, New Haven, 06520, Connecticut, USA

    Guadalupe Garcia-Tsao

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DeLeve, L.D. (2011). Vascular Liver Disease and the Liver Sinusoidal Endothelial Cell. In: DeLeve, L., Garcia-Tsao, G. (eds) Vascular Liver Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-8327-5_2

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