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Entry of Influenza Virus

  • Chapter
Viral Entry into Host Cells

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 790))

Abstract

As a major pathogen of human and certain animal species, influenza virus causes wide spread and potentially devastating disease. To initiate infection, the virus first binds to cellularreceptors comprising either -(2,3 ) or -(2,6) linked sialic acid. Recent advances in our understanding of the influenza virus receptor and viral host species involved have shed light on the molecular mechanism of how influenza virus transmits across species and adapts to a new host. Following receptor binding, influenza viruses are internalized through multiple endocytic pathways, including both clathrin- and non-clathrin-dependent routes, which have recently been visualized at single viral particle level. The viral envelope then fuses with the endosomal membrane in a low pH-dependent manner and the viral genome is released into the cytosol, followed by further transport to the nucleus where genome replication occurs.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Cornell University, Ithaca, New York, USA

    Xiangjie Sun & Gary R. Whittaker

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  1. Xiangjie Sun
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  2. Gary R. Whittaker
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Correspondence to Gary R. Whittaker .

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Editors and Affiliations

  1. Institute for Virology, Hannover Medical School, Hannover, Germany

    Stefan Pöhlmann PhD

  2. German Primate Center, Göttingen, Germany

    Stefan Pöhlmann PhD

  3. Blood Systems Research Institute, and Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA

    Graham Simmons PhD

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Sun, X., Whittaker, G.R. (2006). Entry of Influenza Virus. In: Pöhlmann, S., Simmons, G. (eds) Viral Entry into Host Cells. Advances in Experimental Medicine and Biology, vol 790. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7651-1_4

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