Abstract
Monoclonal antibodies (MAbs) against human tumor antigens have been the subject of extensive investigation as carriers of cytotoxic agents to tumor cells. Promising results, both in vitro and in vivo, have been obtained in studies involving immunoconjugates such as MAb-toxins (Vitetta et al., 1987; Blakey et al., 1988), MAb-drugs (Pietersz, 1990; Koppel, 1990), and radiolabeled MAbs (Goldenberg, 1990). Based on these findings, many such conjugates are currently being evaluated in the clinic.
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References
Bagshawe, K.D., 1989, Towards generating cytotoxic agents at cancer sites. Br. J. Cancer, 60:275.
Bagshawe, K.D., Springer, C.J., Searle, F., Antoniw P., Sharma, S.K., Melton, R.G., Sherwood, R.F.A., 1988, Cytotoxic agent can be generated selectively at cancer sites, Br. J. Cancer. 58:700.
Blakey, D.C., Wawrzynczak, E.J., Wallace, P.M., Thorpe, P.E., 1988, Antibody toxin conjugates: a perspective. Prog. Allergy. 45:50.
Bukhari, M.A., Everett, J.L., and Ross, W.C.J. Glucuronic, Sulphuric and Phosphoric Esters of p-Di-2-chloroethylaminophenol. Biochem. Pharm., 21:963.
Clark, E.A., Shu, G., Ledbetter, J.A., 1985, Role of the bp35 cell surface polypeptide in human B-cell activation. Proc. Natl. Acad. Sci. USA. 82:1766.
Goldenberg, D.M., 1990, Cancer Imaging with Radiolabeled Antibodies,Kluwer Academic Publishers, Boston.
Hellstrom, K.E., Yelton, D.E., Fell, H.P., Beaton, D., Gayle, M., MacLean, M., Kahn, M., Hellstrom, I., 1990. Epitope mapping and use of anti-idiotypic antibodies to the L6 monoclonal antibody. Cancer Res., 50: 2449.
Hellstrom, I., Horn, D., Linsley, P., Brown, J.P., Brankovan, V., Hellstrom, K.E., 1986, Monoclonal mouse antibodies raised against human lung carcinoma. Cancer Res., 46:3917.
Kerr, D.E., Senter, P.D., Burnett, W.V., Hirschberg, D.L., Hellstrom, I., and Hellstrom, K.E., 1990, Antibody-penicillin-V-amidase conjugates kill antigen-positive tumor cells when combined with doxorubicin phenoxyacetamide, Cancer Immunol. Immunother., 31:202.
Koppel, G.A., 1990, Recent advances with monoclonal antibody drug targeting for the treatment of human cancer. Bioconj. Chem., 1:13.
Pietersz, G.A., 1990, The linkage of cytotoxic drugs to monoclonal antibodies for the treatment of cancer. Bioconj. Chem., 1:89.
Sands, H., Jones, P.L., Shah, S.A., Plame, D., Vessella, R.C., and Gallagher, B.M., 1988, Correlation of vascular permeability and blood flow with monoclonal antibody uptake by human clouser and renal cell xenografts. Cancer Res., 48:188.
Senter, P.D., Activation of prodrugs by antibody-enzyme conjugates: A new approach to cancer therapy. FASEB. 4:188.
Senter, P.D., Saulnier, M.G., Schreiber, G.J., Hirschberg, D.L., Brown, J.P., Hellstrom, L, Hellstrom, K.E., 1988, Anti-tumor effect of antibody-alkaline phosphatase conjugates in combination with etoposide phosphate. Proc. Natl. Acad. Sci. USA. 85:4842.
Senter, P.D., Schreiber, G.J., Hirschberg, D.L., Ashe, S.A., Hellstrom, K.E., Hellstrom, L, 1990, Enhancement of the in vitro and in vivo antitumor activities of phosphorylated mitomycin C and etoposide derivatives by monoclonal antibody-alkaline phosphatase conjugates. Cancer Res., 49:5789.
Stanislawski, M., Rousseau, V., Goavec, M., Ito, H., 1989, Immunotoxins containing glucose oxidase and lactoperoxidase with tumoricidal properties: In vitro killing effectiveness in a mouse plasmacytoma cell model Cancer Res., 49:5497.
Thorpe, P.E., 1985, Antibody carriers of cytotoxic agents in cancer therapy: a review, in: “Monoclonal antibodies’ 84: biological and clinical applications,” Editrice Kurtis, Milan.
Vitetta, E.S., Fulton, R.J., May, R.D., Till, M., Uhr, J.W., 1987, Redesigning nature’s poisons to create anti-tumor reagents. Science. 238:1098.
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© 1991 Plenum Press, New York
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Senter, P.D., Wallace, P.M., Svensson, H.P., Kerr, D.E., Hellstrom, I., Hellstrom, K.E. (1991). Activation of Prodrugs by Antibody-Enzyme Conjugates. In: Atassi, M.Z. (eds) Immunobiology of Proteins and Peptides VI. Advances in Experimental Medicine and Biology, vol 303. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6000-1_12
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DOI: https://doi.org/10.1007/978-1-4684-6000-1_12
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