Abstract
The term tissue remodeling describes transient or permanent changes in tissue architecture that involve breaching of histological barriers such as basement membranes, basal laminae, and interstitial stroma [extracellular matrix (ECM)]. Tissue remodeling is important to several stages of wound repair, such as inflammation and granulation tissue formation, and in a variety of other physiological or pathological states. These include ovulation, spermatogenesis, trophoblast implantation, mammary involution following lactation, uterine involution, nerve regeneration, rheumatoid arthritis, tumor invasion, and metastasis formation. A common feature of tissue remodeling involves the production of high levels of extracellular proteolytic activities by parenchymal and/or connective tissue cells. The ECM is organized into highly complex structures, each of which consists of different components including various collagen types, glycoproteins such as fibronectin and laminin, elastin, glycosaminoglycans (GAGs), and proteoglycans. Because these ECM components have distinct hydrolytic requirements for their degradation, remodeling of the ECM involves the action of an array of degradative enzymes.
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Mignatti, P., Rifkin, D.B., Welgus, H.G., Parks, W.C. (1988). Proteinases and Tissue Remodeling. In: Clark, R.A.F. (eds) The Molecular and Cellular Biology of Wound Repair. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0185-9_14
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