Abstract
The ability to monitor and record precise blood pressure fluctuations in research animals is vital to research for human hypertension. Direct measurement of blood pressure via implantable radio telemetry devices is the preferred method for automatic collection of chronic, continuous blood pressure data. Two surgical techniques are described for instrumenting the two most commonly used laboratory rodent species with radiotelemetry devices. The basic rat procedure involves advancing a blood pressure catheter into the abdominal aorta and placing a radio transmitting device in the peritoneal cavity. The mouse technique involves advancing a thin, flexible catheter from the left carotid artery into the aortic arch and placing the telemetry device under the skin along the animal’s flank. Both procedures yield a chronically instrumented model to provide accurate blood pressure data from an unrestrained animal in its home cage.
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5 Suggested Reading
5.1 Mouse Blood Pressure Articles
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Acknowledgments
We gratefully acknowledge the growing community of telemetry users around the world, their inventiveness and willingness to dialogue with their colleagues are responsible for the continuing effort to refine device implantation surgery for the benefit of our animal subjects.
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Huetteman, D.A., Bogie, H. (2009). Direct Blood Pressure Monitoring in Laboratory Rodents via Implantable Radio Telemetry. In: DiPetrillo, K. (eds) Cardiovascular Genomics. Methods in Molecular Biology™, vol 573. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-247-6_4
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DOI: https://doi.org/10.1007/978-1-60761-247-6_4
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