Skip to main content

Khat Addiction

  • Chapter
  • First Online:
Textbook of Addiction Treatment

Abstract

Khat leaves are traditionally consumed in African and Arab countries around the Horn of Africa. The central and peripheral stimulant alkaloid cathinone (S-(-)-a-aminopropiophenone) is considered to be the main psychoactive compound in the khat leaves. The leaves and tender stems are usually chewed and kept in a tight wad in the cheek pocket. Within about 15–30 minutes, the user experiences physiological excitability, euphoria, talkativeness, and flow of ideas. While khat production and consumption is popular in traditional user countries and use patterns swiftly change to excessive usage, particularly in East Africa, the substance is treated as illegal in the rest of the world. Today, cathinone is listed in Schedule I of the 1971 International Convention on Psychotropic Substances, although the leaves of khat are not internationally controlled. Khat use is associated with a number of mental health problems. A problem with diagnosis of khat use disorders is that established criteria are not easily applicable. Since the first edition of this textbook, some research has been done on khat; however, the current empirical knowledge base is still limited on prevalence and use patterns; most studies that associate khat use with mental and physical health problems have weak designs and treatment studies are rare. There is a need to build up research and treatment capacities in the main khat use countries. There is also a need to develop adequate legal regulations, monitoring systems, and public health responses that moderate between economic, cultural, and health viewpoints.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Abbay AG, Mulatu AT, Azadi H. Community knowledge, perceived beliefs and associated factors of mental distress: a case study in northern Ethiopia. Int. J. Environ. Res. Public Health 2018;15:2423. https://doi.org/10.3390/ijerph15112423.

  2. Abdelwahab SI, Alsanosy RM, Rahim BEA, Mohan S, Taha S, Elhassan M, El-Setouhy M. Khat (Catha edulis Forsk.) dependence potential and pattern of use in Saudi Arabia. BioMed Res Int. 2015;2015:604526.

    Article  Google Scholar 

  3. Abdeta T, Tolessa D, Adorjan K, Abera M. Prevalence, withdrawal symptoms and associated factors of khat chewing among students at Jimma University, Ethiopia. BMC Psychiatry. 2017;17:142.

    Article  Google Scholar 

  4. Abednego M, Veltrup C, Warsame AH, Isse MM, Widmann M, Ndetei D, Mutisu V, Odenwald M. Developing an integrated treatment for PTSD and khat dependence: results from a case series among Somali refugees. Paper presented at the XIV conference of European Society for Traumatic Stress Studies, 10–13 June 2015, Vilnius, 2015.

    Google Scholar 

  5. Adorjan K, Odenwald M, Widmann M, Tesfaye M, Tessema F, Toennes S, Suleman S, Papiol S, Soboka M, Mekonnen Z, Rockstroh B, Rietschel M, Pogarell O, Susser E, Schulze TG. Khat use and occurrence of psychotic symptoms in the general male population in Southwestern Ethiopia: evidence for sensitization by traumatic experiences. World Psychiatry. 2017;16(3):323. https://doi.org/10.1002/wps.20470.

    Article  Google Scholar 

  6. Al’Absi M, Grabowski J. Concurrent use of tobacco and khat: added burden on chronic disease epidemic. Addiction. 2012;107(2):451–2.

    Article  Google Scholar 

  7. Al-Motarreb A, Al-Habori M, Broadley KJ. Khat chewing, cardiovascular diseases and other internal medical problems: the current situation and directions for future research. J Ethnopharmacol. 2010;132(3):540–8.

    Article  CAS  Google Scholar 

  8. Alsanusy R, El-Sethouhy M. Why would khat chewers quit? An in-depth qualitative study on Saudi khat quitters. Subst Abus. 2013;34:389–95. https://doi.org/10.1080/08897077.2013.783526.

    Article  Google Scholar 

  9. Al-Shahethi AH, Zaki RA, Al-Serouri AWA, Awang Bulgiba A. Maternal, prenatal and traditional practice factors associated with perinatal mortality in Yemen. Women Birth. 2019;32(2):e204–5. https://doi.org/10.1016/j.wombi.2018.06.016.

    Article  Google Scholar 

  10. Anderson D, Beckerleg S, Hailu D, Klein A. The Khat controversy: stimulating the debate on drugs. Oxford: Berg; 2007.

    Google Scholar 

  11. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, fifth edition (DSM-5). Washington, D.C.: American Psychiatric Association; 2013.

    Book  Google Scholar 

  12. Awas M, Kebede D, Alem A. Major mental disorders in Butajira, southern Ethiopia. Acta Psychiatr Scand. 1999;397(Suppl):56–64.

    Article  CAS  Google Scholar 

  13. Beckerleg S. What harm? Kenyan and Ugandan perspectives on khat. Afr Aff. 2006;105(419):219–41. https://doi.org/10.1093/afraf/adi105.

    Article  Google Scholar 

  14. Bimerew MS, Sonn FCT, Korlenbout WP. Substance abuse and the risk of readmission of people with schizophrenia at Amanuel Psychiatric Hospital, Ethiopia. Curationis. 2007;30(2):74–81.

    Article  CAS  Google Scholar 

  15. Colzato LS, Ruiz M, van den Wildenberg WP, Bajo M, Hommel B. Long-term effects of chronic khat use: impaired inhibitory control. Front Psychol. 2010;1:129.

    Google Scholar 

  16. Colzato LS, Ruiz MJ, van den Wildenberg WP, Hommel B. Khat use is associated with impaired working memory and cognitive flexibility. PLoS One. 2011;6(6):e20602.

    Article  CAS  Google Scholar 

  17. Colzato LS, Ruiz MJ, van den Wildenberg WP, Hommel B. Khat use is associated with increased response conflict in humans. Hum Psychopharmacol Clin Exp. 2012;27(3):315–21.

    Article  CAS  Google Scholar 

  18. Duresso SW, Matthews AJ, Ferguson SG, Bruno R. Using the severity of dependence scale to screen for DSM-5 khat use disorder. Hum Psychopharmacol Clin Exp. 2018;33:e2653. https://doi.org/10.1002/hup.2653.

    Article  Google Scholar 

  19. Duresso SW, Bruno R, Matthews AJ, Ferguson SG. Khat withdrawal symptoms among chronic khat users following a quit attempt: an ecological momentary assessment study. Psychol Addict Behav. 2018;32(3):320–6.

    Article  Google Scholar 

  20. Duresso SW, Bruno R, Matthews AJ, Ferguson SG. Stopping khat use: predictors of success in an unaided quit attempt. Drug Alcohol Rev. 2018;37(Suppl 1):235–9. https://doi.org/10.1111/dar.12622.

    Article  Google Scholar 

  21. Duresso SW, Matthews AJ, Ferguson SG, Bruno R. Is khat use a valid diagnostic entity? Addiction. 2016;111:1666–76.

    Article  Google Scholar 

  22. Elmi AS. The chewing of khat in Somalia. J Ethnopharmacol. 1983;8(2):163–76.

    Article  CAS  Google Scholar 

  23. Eticha T, Teklu A, Ali D, Solomon G, Alemayehu A. Factors associated with medication adherence among patients with schizophrenia in Mekelle, northern Ethiopia. PLoS One. 2015;10(3):e0120560. https://doi.org/10.1371/journal.pone.0120560.

    Article  CAS  Google Scholar 

  24. European Monitoring Centre for Drugs and Drug Addiction. European drug report: trends and developments. Luxembourg: Publication Office of the European Union; 2018.

    Google Scholar 

  25. Gatter P. Politics of Qat: the role of a drug in ruling Yemen. Wiesbaden: Reichert; 2012.

    Google Scholar 

  26. Gebrie A, Alebel A, Zegeye A, Tesfaye B. Prevalence and predictors of khat chewing among Ethiopian university students: a systematic review and meta-analysis. PLoS One. 2018;13(4):e0195718. https://doi.org/10.1371/journal.pone.0195718.

    Article  CAS  Google Scholar 

  27. Griffiths P, Lopez D, Sedefov R, Gallegos A, Hughes B, Noor A, Royuela L. Khat use and monitoring drug use in Europe: the current situation and issues for the future. J Ethnopharmacol. 2010;132(3):578–83.

    Article  Google Scholar 

  28. Halbach H. Medical aspects of the chewing of khat leaves. Bull World Health Organ. 1972;47(1):21–9.

    CAS  Google Scholar 

  29. Hansen P. The ambiguity of khat in Somaliland. J Ethnopharmacol. 2010;132(3):590–9.

    Article  Google Scholar 

  30. Haile D, Lakew Y. Khat chewing practice and associated factors among adults in Ethiopia: further analysis using the 2011 demographic and health survey. PLoS One. 2015;10(6):e0130460.

    Article  Google Scholar 

  31. Hoffman R, al’Absi M. Working memory and speed of information processing in chronic khat users: preliminary findings. Eur Addict Res. 2012;19(1):1–6.

    Article  Google Scholar 

  32. Ismail AA, El Sanosy RM, Rohlman DS, El-Setouhy M. Neuropsychological functioning among chronic khat users in Jazan region, Saudi Arabia. Subst Abus. 2014;35:235–44.

    Article  Google Scholar 

  33. Kalix P. Pharmacological properties of the stimulant khat. Pharmacol Ther. 1990;48(3):397–416.

    Article  CAS  Google Scholar 

  34. Kassim S, Islam S, Croucher R. Validity and reliability of a severity of dependence Scale for khat (SDS-khat). J Ethnopharmacol. 2010;132(3):570–7.

    Article  Google Scholar 

  35. Kassim S, Islam S, Croucher RE. Correlates of nicotine dependence in U.K. resident Yemeni khat chewers: a cross-sectional study. Nicotine Tob Res. 2011;13:1240.

    Article  Google Scholar 

  36. Kassim S, Hawash A, Johnston A, Croucher R. Validation of self-reported khat chewing amongst khat chewers: an exploratory study. J Ethnopharmacol. 2012;140(1):193–6.

    Article  Google Scholar 

  37. Kassim S, Croucher R, al’Absi M. Khat dependence syndrome: a cross sectional preliminary evaluation amongst UK-resident Yemeni khat chewers. J Ethnopharmacol. 2013;146(3):835–41.

    Article  Google Scholar 

  38. Kennedy JG, Teague J, Fairbanks L. Qat use in North Yemen and the problem of addiction: a study in medical anthropology. Cult Med Psychiatry. 1980;4(4):311–44.

    Article  CAS  Google Scholar 

  39. Klein A, Beckerleg S, Hailu D. Regulating Khat – dilemmas and opportunities for the international drug control system. Int J Drug Policy. 2009;20(6):509–13.

    Article  Google Scholar 

  40. Klein A. The Khat ban in the UK. What about the ‘scientific’ evidence? Anthropol Today. 2013;29(5):6–8.

    Article  Google Scholar 

  41. Klein A. Framing the chew: narratives of development, drugs and danger with regard to khat (catha edulis). In: Labate BC, Cavnar C, editors. Prohibition, religious freedom, and human rights: regulating traditional drug use. Berlin/Heidelberg: Springer; 2014.

    Google Scholar 

  42. Krikorian AD. Kat and its use: an historical perspective. J Ethnopharmacol. 1984;12:115–78.

    Article  CAS  Google Scholar 

  43. Lifson AR, Workneh S, Shenie T, Ayana DA, Melaku Z, Bezabih L, Waktola HT, Dagne B, Hilk R, Winters KC, Slater L. Frequent use of khat, an amphetamine-like substance, as a risk factor for poor adherence and lost to follow-up among patients new to HIV care in Ethiopia. AIDS Res Hum Retrovir. 2017;33(10):995–8. https://doi.org/10.1089/aid.2016.0274.

    Article  CAS  Google Scholar 

  44. Mihretu A, Nhunzvi C, Fekadu A, Norton S, Teferra S. Definition and validity of the construct “Problematic Khat Use”: a systematic review. Eur Addict Res. 2019;25(4):161–71. https://doi.org/10.1159/000499970.

    Article  Google Scholar 

  45. Nabuzoka D, Badhadhe FA. Use and perception of khat among young Somalis in a UK city. Addict Res. 2000;8(1):5–26.

    Article  Google Scholar 

  46. Nakajima M, Jebena MG, Taha M, Tesfaye M, Gudina E, Lemieux A, Hoffman R, al’Absi M. Correlates of khat use during pregnancy: a cross-sectional study. Addict Behav. 2017;73:178–84.

    Article  Google Scholar 

  47. Nakajima M, Dokam A, Alsameai A, AlSoofi M, Khalil N, al’Absi M. Severity of Khat dependence among adult Khat chewers: the moderating influence of gender and age. J Ethnopharmacol. 2014;155(3):1467–72.

    Article  CAS  Google Scholar 

  48. Ndetei DM, Khasakhala LI, Ongecha-Owuor FA, Kuria MW, Mutiso V, Kokonya DA. Prevalence of substance abuse among patients in general medical facilities in Kenya. Subst Abus. 2009;30(2):182–90.

    Article  Google Scholar 

  49. Ndetei DM, Khasakhala L, Mathai M, Mutiso V, Mbwayo A, Warsame A, Isse M, Mohamud RO, Mursal BM, Abdi MH. Mental health needs assessment of Somali urban refugees. A monograph of Africa Mental Health Foundation. Nairobi: Africa Mental Health Foundation; 2014.

    Google Scholar 

  50. Nencini P, Ahmed AM, Amiconi G, Elmi AS. Tolerance develops to sympathetic effects of khat in humans. Pharmacology. 1984;28(3):150–4.

    Article  CAS  Google Scholar 

  51. Nutt D, King LA, Phillips LD. Drug harms in the UK: a multicriteria decision analysis. Lancet. 2010;376:1558–65.

    Article  Google Scholar 

  52. Odenwald M, Neuner F, Schauer M, Elbert TR, Catani C, Lingenfelder B, Hinkel H, Hafner H, Rockstroh B. Khat use as risk factor for psychotic disorders: a cross-sectional and case control study in Somalia. BMC Med. 2005;3(1):5.

    Article  Google Scholar 

  53. Odenwald M. Chronic khat use and psychotic disorders: a review of the literature and future prospects. Sucht. 2007;53(1):9–22. https://doi.org/10.1463/2007.01.03.

    Article  Google Scholar 

  54. Odenwald M, Hinkel H, Schauer E, Schauer M, Elbert T, Neuner F, Rockstroh B. Use of khat and posttraumatic stress disorder as risk factors for psychotic symptoms: a study of Somali combatants. Soc Sci Med. 2009;69(7):1040–8.

    Article  Google Scholar 

  55. Odenwald M, Klein A, Warfa N. Introduction to the special issue: the changing use and misuse of khat (Catha edulis)–tradition, trade and tragedy. J Ethnopharmacol. 2010;132(3):537–9.

    Article  Google Scholar 

  56. Odenwald M, Warfa N, Bhui K, Elbert T. The stimulant khat–another door in the wall? A call for overcoming the barriers. J Ethnopharmacol. 2010;132(3):615–9.

    Article  Google Scholar 

  57. Odenwald M, al’Absi M. Khat use and related addiction, mental health and physical disorders: the need to address a growing risk. East Mediterr Health J. 2017;23(3):236–44.

    Article  Google Scholar 

  58. Ongeri L, Kirui F, Muniu E, Manduku V, Kirumbi L, Atwoli L, Agure S, Wanzala P, Kaduka L, Karimi M, Mutisya R, Echoka E, Mutai J, Mathu D, Mbakaya C. Khat use and psychotic symptoms in a rural Khat growing population in Kenya: a household survey. BMC Psychiatry. 2019;19:137.

    Article  Google Scholar 

  59. Orlien SMS, Sandven I, Berhe NB, Ismael NY, Ahmed TA, Stene-Johansen K, Gundersen SG, Morgan MY, Johannessen A. Khat chewing increases the risk for developing chronic liver disease: a hospital-based case-control study. Hepatology. 2018;68(1):248–57.

    Article  Google Scholar 

  60. Suwaidi JA, Ali WM, Aleryani SL. Cardiovascular complications of Khat. Clin Chim Acta. 2013;419:11–4.

    Article  Google Scholar 

  61. Teferra S, Hanlon C, Alem A, Jacobsson L, Shibre T. Khat chewing in persons with severe mental illness in Ethiopia: a qualitative study exploring perspectives of patients and caregivers. Transcult Psychiatry. 2011;48(4):455–72.

    Article  Google Scholar 

  62. Teklie H, Gonfa G, Getachew T, Defar A, Bekele A, Bekele A, Gelibo T, Amenu K, Tadele T, Taye G, Getinet M, Chala F, Mudie K, Guta M, Feleke Y, Shiferaw F, Tadesse Y, Yadeta D, Gbebremichael M, Girma Y, Kebede T, Teferra S. Prevalence of Khat chewing and associated factors in Ethiopia: findings from the 2015 national non-communicable diseases STEPS survey. Ethiop J Health Dev. 2017;31(Special Issue):320–30.

    Google Scholar 

  63. United Nations Office on Drugs and Crime. World drug report 2012. New York: United Nations; 2012.

    Book  Google Scholar 

  64. Warfa N, Klein A, Bhui K, Leavey G, Craig T, Stansfeld SA. Khat use and mental illness: a critical review. Soc Sci Med. 2007;65:309–18.

    Article  Google Scholar 

  65. Weir S. Qat in Yemen: consumption and social change. London: British Museum Publications Limited; 1985.

    Google Scholar 

  66. Widmann M, Warsame AH, Mikulica J, von Beust J, Isse MM, Ndetei D, al’Absi M, Odenwald M. Khat use, PTSD and psychotic symptoms among Somali refugees in Nairobi – a pilot study. Front Public Health. 2014;2:71.

    Article  Google Scholar 

  67. Widmann, M., Apondi, B., Musau, A., Warsame, A.H., Isse, M. M., Mutiso V,·Veltrup C, Ndetei D, Odenwald M. Comorbid psychopathology and everyday functioning in a brief intervention study to reduce khat use among Somalis living in Kenya: description of baseline multimorbidity, its effects of intervention and its moderation effects on substance use. Soc Psychiatry Psychiatr Epidemiol, 2017, 52, 1425–1434.

    Article  Google Scholar 

  68. World Health Organization. WHO expert committee on drug dependence, thirty-fourth report, WHO technical report series no. 942. Washington, D.C.: World Health Organization; 2006.

    Google Scholar 

  69. Zyoud SH. Bibliometric analysis on global Catha edulis (khat) research production during the period of 1952–2014. Glob Health. 2015;11:39.

    Article  Google Scholar 

Further Reading

  • Klein A, Beckerleg S, Hailu D. Regulating Khat – dilemmas and opportunities for the international drug control system. Int J Drug Policy. 2009;20(6):509–13.

    Article  Google Scholar 

  • Mihretu A, Nhunzvi C, Fekadu A, Norton S, Teferra S. Definition and validity of the construct “Problematic Khat Use”: a systematic review. Eur Addict Res. 2019;25(4):161–71. https://doi.org/10.1159/000499970.

    Article  Google Scholar 

  • Odenwald M, Warfa N, Bhui K, Elbert T. The stimulant khat–another door in the wall? A call for overcoming the barriers. J Ethnopharmacol. 2010;132(3):615–9.

    Article  Google Scholar 

  • Odenwald M, al’Absi M. Khat use and related addiction, mental health and physical disorders: the need to address a growing risk. East Mediterr Health J. 2017;23(3):236–44.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Michael Odenwald .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Odenwald, M., Klein, A., Warfa, N. (2021). Khat Addiction. In: el-Guebaly, N., Carrà, G., Galanter, M., Baldacchino, A.M. (eds) Textbook of Addiction Treatment. Springer, Cham. https://doi.org/10.1007/978-3-030-36391-8_17

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-36391-8_17

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-36390-1

  • Online ISBN: 978-3-030-36391-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics