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Cognitive Impairment in Aneurysmal Subarachnoid Hemorrhage Patients with Delayed Cerebral Infarction: Prevalence and Pattern

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Neurovascular Events After Subarachnoid Hemorrhage

Part of the book series: Acta Neurochirurgica Supplement ((NEUROCHIRURGICA,volume 120))

Abstract

Background: Cognitive deficits commonly occur after aneurysmal subarachnoid hemorrhage (aSAH) and clinical understanding is important for treatment and rehabilitation. Delayed cerebral infarction was shown to be related to poor outcome. Data on delayed cerebral infarction-related cognitive impairment were lacking.

Objective: We investigated the prevalence and pattern of delayed cerebral infarction-associated cognitive impairment.

Methods: We carried out a prospective observational and diagnostic accuracy study in Hong Kong in patients aged 21ā€“75 years with aSAH who had been admitted within 96 h of ictus. The domain-specific neuropsychological assessment battery at 1 year after ictus was used for cognitive assessments. A cognitive domain deficit was defined as a cognitive domain z score less than āˆ’1.65 (below the fifth percentile). Cognitive impairment was defined by two or more cognitive domain deficits. The current study is registered at ClinicalTrials.gov of the U.S. National Institutes of Health (NCT01038193).

Results: One hundred and twenty aSAH patients were recruited. Patients with delayed cerebral infarction (DCI) have cognitive impairment more frequently (22 % vs 11 %; odds ratio: 2.2, 0.6 to 7.8, pā€‰=ā€‰0.192). Cognitive domain deficits commonly affected in aSAH patients with delayed cerebral infarction were verbal memory, language, and visuospatial memory and skill domains, and were relatively uncommon in aSAH patients without delayed cerebral infarction.

Conclusion: In patients with aSAH, delayed cerebral infarction was associated with a specific pattern of cognitive domain deficits. The pathophysiology should be further investigated.

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Conflict of Interest Statement/Financial Disclosure

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, 4/F Clinical Science Building, 30-32 Ngan Shing Street, Shatin, NT, Hong Kong SAR, China

    Alberto Chi Ho Chu MRCS,Ā George Kwok Chu Wong MD,Ā Sandy Wai Lam BSocSc,Ā Karine Ngai BSocScĀ &Ā Wai Sang Poon FRCS

  2. Department of Psychological Studies, The Hong Kong Institute of Education, 10 Lo Ping Road, Tai Po, NT, Hong Kong

    Adrian Wong PhD

  3. Division of Neurology, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, 4/F Clinical Science Building, 30-32 Ngan Shing Street, Shatin, NT, Hong Kong SAR, China

    Vincent Mok MD

Authors
  1. Alberto Chi Ho Chu MRCS
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  2. George Kwok Chu Wong MD
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  3. Sandy Wai Lam BSocSc
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  4. Adrian Wong PhD
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  5. Karine Ngai BSocSc
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  6. Wai Sang Poon FRCS
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  7. Vincent Mok MD
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Corresponding author

Correspondence to George Kwok Chu Wong MD .

Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland

    Javier Fandino

  2. Department of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland

    Serge Marbacher

  3. Department of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland

    Ali-Reza Fathi

  4. Department of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland

    Carl Muroi

  5. Department of Neurosurgery Neurointensive Care Unit, University Hospital Zurich, Zurich, Switzerland

    Emanuela Keller

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Chu, A.C.H. et al. (2015). Cognitive Impairment in Aneurysmal Subarachnoid Hemorrhage Patients with Delayed Cerebral Infarction: Prevalence and Pattern. In: Fandino, J., Marbacher, S., Fathi, AR., Muroi, C., Keller, E. (eds) Neurovascular Events After Subarachnoid Hemorrhage. Acta Neurochirurgica Supplement, vol 120. Springer, Cham. https://doi.org/10.1007/978-3-319-04981-6_51

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  • DOI: https://doi.org/10.1007/978-3-319-04981-6_51

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-04980-9

  • Online ISBN: 978-3-319-04981-6

  • eBook Packages: MedicineMedicine (R0)

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