Abstract
The CAPRISA 007 trial, was a pilot, proof of concept, matched pair cluster randomised control trial evaluating the impact of conditional cash transfers to reduce HIV and HSV-2 acquisition in adolescent high-school students. The trial enrolled Grades 9 and 10 learners regardless of age, gender or HIV status from 14 randomly selected secondary schools in rural KwaZulu-Natal. The baseline bio-behavioural assessments highlight the overall high prevalence of HIV and Herpes simplex-2 (HSV-2) infections with notable age–sex differences in both infections in adolescent girls compared to their male peers. This chapter describes the rationale, study design and experiences of conducting the CAPRISA 007 trial that assessed the impact of a cash-incentivised multi-component structural and behavioural intervention for HIV and HSV-2 prevention in high-school learners in rural KwaZulu-Natal.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Abdool Karim Q, Abdool Karim SS, Singh B, Short R, Ngxongo S. Seroprevalence of HIV infection in rural South Africa. AIDS. 1992; 6: 1535–9.
Gregson S, Nyamukapa CA, Garnett GP, Mason PR, Zhuwau T, Carael M, et al. Sexual mixing patterns and sex-differentials in teenage exposure to HIV infection in rural Zimbabwe. Lancet. 2002; 359(9321): 1896–903.
Pettifor AE, Rees HV, Kleinschmidt I, Steffenson AE, MacPhail C, Hlongwa-Madikizela L, et al. Young people’s sexual health in South Africa: HIV prevalence and sexual behaviors from a nationally representative household survey. AIDS. 2005; 19(14): 1525–34.
UNAIDS. The gap report. Available from: http://www.unaids.org/en/media/unaids/contentassets/documents/unaidspublication/2014/UNAIDS_Gap_report_en.pdf [Accessed: 16 OCtober 2014]. Geneva, Switzerland: Joint United Nations Programme on HIV/AIDS (UNAIDS); 2014.
Department of Health. The 2013 National Antenatal Sentinel HIV Prevalence Survey South Africa. Pretoria: Department of Health; 2015.
Abdool Karim Q, Kharsany AB, Frohlich JA, Werner L, Mlotshwa M, Madlala BT, et al. HIV incidence in young girls in KwaZulu-Natal, South Africa–public health imperative for their inclusion in HIV biomedical intervention trials. AIDS Behav. 2012; 16(7): 1870–6.
Kharsany AB, Frohlich JA, Yende-Zuma N, Mahlase G, Samsunder N, Dellar RC, et al. Trends in HIV Prevalence in Pregnant Women in Rural South Africa. J Acquir Immune Defic Syndr. 2015; 70(3): 289–95.
Cowan FM, Pascoe SJS, Langhaug LF, Mavhu W, Chidiya S, Jaffar S, et al. The Regai Dzive Shiri project: results of a randomized trial of an HIV prevention intervention for youth. AIDS. 2010; 24(16): 2533–44.
Ross DA, Changalucha J, Obasi AI, Todd J, Plummer ML, Cleophas-Mazige B, et al. Biological and behavioural impact of an adolescent sexual health intervention in Tanzania: a community-randomized trial. AIDS. 2007; 21(14): 1943–55.
Doyle AM, Ross DA, Maganja K, Baisley K, Masesa C, Andreasen A, et al. Long-term biological and behavioural impact of an adolescent sexual health intervention in Tanzania: follow-up survey of the community-based MEMA kwa Vijana Trial. PLoS Medicine. 2010; 7(6): e1000287.
Baird SJ, Garfein RS, McIntosh CT, Ozler B. Effect of a cash transfer programme for schooling on prevalence of HIV and herpes simplex type 2 in Malawi: a cluster randomised trial. Lancet. 2012; 379(9823): 1320–9.
de Walque D, Dow WH, Nathan R, Abdul R, Abilahi F, Gong E, et al. Incentivising safe sex: a randomised trial of conditional cash transfers for HIV and sexually transmitted infection prevention in rural Tanzania. BMJ Open. 2012; 2: e000747.
Michielsen K, Chersich MF, Luchters S, De Koker P, Van Rossem R, Temmerman M. Effectiveness of HIV prevention for youth in sub-Saharan Africa: systematic review and meta-analysis of randomized and nonrandomized trials. AIDS. 2010; 24(8): 1193–202.
Abdool Karim Q, Kharsany ABM, Leask K, Ntombela F, Humphries H, Frohlich JA, et al. Prevalence of HIV, HSV-2 and pregnancy among high school students in rural KwaZulu-Natal, South Africa: a bio-behavioural cross-sectional survey. Sexually Transmitted Infections. 2014; 90(8):620–6.
Abdool Karim Q, Leask K, Kharsany A, Humphries H, Ntombela F, Samsunder N, et al. Impact of conditional cash incentives on HSV-2 and HIV prevention in rural South African high school students: results of the CAPRISA 007 cluster randomized controlled trial [Abstract TUAC0101LB]. Eighth International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention. Vancouver; 2015.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer International Publishing AG
About this chapter
Cite this chapter
Humphries, H., Kharsany, A.B.M., Leask, K., Ntombela, F., Abdool Karim, Q. (2017). The Impact of Conditional Cash Transfers in Reducing HIV in Adolescent Girls and Boys (RHIVA): The CAPRISA 007 Matched Pair, Cluster Randomised Controlled Trial. In: Abdool Karim, Q., Abdool Karim, S., Baxter, C. (eds) The CAPRISA Clinical Trials: HIV Treatment and Prevention. Springer, Cham. https://doi.org/10.1007/978-3-319-47518-9_6
Download citation
DOI: https://doi.org/10.1007/978-3-319-47518-9_6
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-47517-2
Online ISBN: 978-3-319-47518-9
eBook Packages: MedicineMedicine (R0)