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Severe Cutaneous Adverse Reactions

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Braun-Falco’s Dermatology

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Abstract

There are a variety of drug reactions that can be severe and life-threatening. Among these are Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Both are characterized by erythematous lesions, blisters, and mucosal involvement that together lead to a clinical picture resembling that of a severe burn. Together with erythema multiforme, SJS and TEN comprise a spectrum of severe blistering skin reactions. In the following, they are considered in detail, whereas other extensive cutaneous drug eruptions, including hypersensitivity syndrome, acute generalized exanthematous pustulosis, and erythroderma, are briefly discussed.

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Authors and Affiliations

  1. Klinik und Poliklinik für Dermatologie, Universitätsklinikum Carl Gustav Carus, Fetscherstraße 74, 01307, Dresden, Germany

    Maja Mockenhaupt Prof. Dr. med.

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  1. Maja Mockenhaupt Prof. Dr. med.
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Editors and Affiliations

  1. Traubinger Straße 45A, 82327, Tutzing, Germany

    Walter H.C. Burgdorf MD  & Otto Braun-Falco  & 

  2. Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität München, Frauenlobstraße 9-11, 80337, München, Germany

    Gerd Plewig F.R.C.P.

  3. Thiewall 11, 31840, Hess.-Oldendorf/Lachem, Germany

    Helmut H. Wolff

  4. Klinik und Poliklinik für Dermatologie, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93042, Regensburg, Germany

    Michael Landthaler

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Mockenhaupt, M. (2009). Severe Cutaneous Adverse Reactions. In: Burgdorf, W.H., Plewig, G., Wolff, H.H., Landthaler, M., Braun-Falco, O. (eds) Braun-Falco’s Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29316-3_34

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  • DOI: https://doi.org/10.1007/978-3-540-29316-3_34

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-29312-5

  • Online ISBN: 978-3-540-29316-3

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