Zusammenfassung
Entwicklungsstörungen des Metanephros können zu einer ein- oder beidseitigen Nierenhypoplasie oder -dysplasie führen (Bernstein 1992; Watkins et al. 1999; Tabelle 17-1). Diese Störungen sind angeboren, aber nur selten hereditär. Beide sind gelegentlich mit einem Fehlbildungssyndrom assoziiert (s. Kap. 18). Bei der Nierenhypoplasie ist die Anzahl der Nephrone und evtl. deren Größe reduziert, deren Struktur aber primär nicht verändert. Bei der Nierendysplasie ist hingegen die Nierenentwicklung qualitativ gestört und findet man häufig gleichzeitig andere angeborene Störungen des Urogenitalapparates. Nierenhypoplasie und -dysplasie kommen häufig kombiniert vor.
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Literatur
Al-Khaldi N, Watson AR, Zuccollo J, Twining P, Rose DH (1994) Outcome of antenatally detected cystic dysplastic kidney disease. Arch Dis Child 70: 520–522
Bernstein J (1992) Renal hypoplasia and dysplasia. In: Edelmann CM (ed) Pediatric kidney disease. Little, Brown, Boston, pp 1121–1137
Broyer M, Soto B, Gagnadoux MF (1997) Oligomeganephronic renal hypoplasia. Adv Nephrol 26: 47–63
Cochat P, Murat FJ, Guibaud L et al. (2000) La dysplasie rénale multikystique. In: Guignard JP, Gouyon JB, Simeoni U (eds) Néphrologie périnatale. Elsevier, Paris, pp 83–92
Drozdz D, Drozdz M, Gretz N, Möhring K, Mehls O, Schärer K (1998) Progression to end-stage renal disease in children with posterior urethral valves. Pediatr Nephrol 12: 630–636
Feldenberg 1R, Siegel NJ (2000) Clinical course and outcome for children with multycystic dysplastic kidneys. Pediatr Nephrol 14: 1098–1101
Flack CE, Bellinger MF (1993) The multicystic dysplastic kidney and contralateral vesicoureteral reflux: Protection of the solitary kidney. J Urol 150: 1873–1874
John U, Rudnik-Schöneborn S, Zerres K, Misselwitz J (1998) Kidney growth and renal function in unilateral multicystic kidney disease. Pediatr Nephrol 12: 567–571
Liapis H, YuH, Flath A, Steinhardt GF (1997) Increased expression of platelet-derived growth factor α and collagenous matrix proteins in congenital multicystic renal dysplasia. Nephron 76: 161–170
Mesrobian HG, Rushton HG, Bulas D (1993) Unilateral renal agenesis may result from in utero regression of multicystic renal dysplasia. J Urol 150: 793–794
Minevich E, Wacksman J, Phipps L et al. (1997) The importance of accurate diagnosis and early close follow-up in patients with suspected dysplastic kidneys. J Urol 158: 1301–1304
Moerman P, Fryns JP, Sastrowijoto SM et al. (1994) Hereditary renal dysplasia: New observations and hypotheses. Pediatr Pathol 14: 405–410
Palmer LS, Andros GJ, Maizels M, Kaplow WE, Firlit CF (1997) Management considerations for treating vesicoureteral reflux in children with solitary kidney. Urology 49: 604–608
Reitelman C, Becker CJ, Chang CH, Perlmuter AD (1992) Infected multicystic kidney. Urology 34: 157–159
Roach PJ, Treves St, Davis RT, Tello RJ, Perez-Atyade A, Paltiel HJ (1995) Renal dysplasia in infants: Appearance on 99mTcDMSA scintigraphy. Pediatr Radiol 25: 472–475
Rottenberg GT, Gordon I, de Bruyn R (1992) The natural history of the multicystic dysplastic kidneys in children. Br J Radiol 70: 347–350
Rudnik-Schöneborn S, John U, Ehrich JHI, Misselwitz J, Zerres K (1998) Clinical features of unilateral multicystic renal dysplasia in children. Eur J Pediatr 157: 666–672
Sanders RC (1992) In utero sonography of genito-urinary anomalies. Urol Radiol 14: 29–33
Sanders RC, Nussbaum AR, Solez K (1998) Renal dysplasia: Sonographic findings. Radiology 167: 623–626
Srivastava T, Garola RE, Hellerstein G (1999) Autosomal dominant inheritance of multicystic dysplastic kidney. Pediatr Nephrol 13: 481–483
Strife JL, Souza AS, Kirks DR, Strife CF, Gelfaud MJ, Wacksman J (1993) Multicystic dysplastic kidney in children: US follow-up. Radiology 186: 785–788
Watkins SL, McDonald RA, Avner ED (1999) Renal dysplasia and miscellaneous cystic disorder. In: Barratt TM, Avner ED, Harmon WE (eds) Pediatric nephrology, 4th edn. Lippincott, Williams&Wilkins, Baltimore, pp 415–425
Winyard PJ, Woolf AS, Dressier GR, Sams VR, Risdon RA (1996) The PAX2 transcription factor is expressed in cystic and hyperproliferative dysplastic epithelia in human kidney malformations. J Clin Invest 98: 451–459
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Schärer, K. (2002). Nierenhypoplasie und -dysplasie. In: Schärer, K., Mehls, O. (eds) Pädiatrische Nephrologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56378-2_17
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