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Hematopoietic Transcriptional Regulation by the Myeloid Zinc Finger Gene, MZF-1

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Molecular Aspects of Myeloid Stem Cell Development

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 211))

Summary

Transcriptional regulators control much of hematopoiesis. One such transcriptional regulator is the myeloid zinc finger gene MZF-1. MZF-1 has been localized to the telomere of chromosome 19q, where a large number of related zinc finger genes reside. It has been found to be essential in granulopoiesis. It is a bi-functional transcriptional regulator, repressing transcription in non-hematopoietic cells, and activating transcription in cells of hematopoietic origins. Its consensus DNA binding site has been isolated, and sites in several promoters of myeloid-specific genes, such as CD34, lactoferrin, and myeloperoxidase, have been defined. In co-transfection experiments MZF-1 has been found to regulate transcription from the CD34 promoter.

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Authors and Affiliations

  1. Hematology/Oncology and the Walther Oncology Center, Indiana University Medical Center, 975 W. Walnut St., Indianapolis, IN, 46202, USA

    R. Hromas, M. Klemsz & Dawei Xu

  2. Cancer Center, UT Medical Branch at Galveston, Galveston, TX, USA

    B. Davis

  3. Molecular Oncology, Wistar Institute, Philadelphia, PA, USA

    F. J. Rauscher III

  4. Harvard Medical School, Hematology, Beth Israel Hospital, Boston, MA, USA

    D. Tenen

  5. Miami University, Oxford, OH, USA

    S. Hoffman

  6. Pediatric Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI, USA

    J. F. Morris

Authors
  1. R. Hromas
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  2. B. Davis
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  3. F. J. Rauscher III
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  4. M. Klemsz
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  5. D. Tenen
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  6. S. Hoffman
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  7. Dawei Xu
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  8. J. F. Morris
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Editor information

Editors and Affiliations

  1. Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bldg. 37, Rm. 1 B16, 37 Convent Drive MSC 4255, Bethesda, MD, 20892-4255, USA

    Linda Wolff Ph.D. (Senior Investigator) (Senior Investigator)

  2. Department of Pathology, Yale University School of Medicine, P.O. Box 208023, New Haven, CT, 06520-8023, USA

    Archibald S. Perkins M.D., Ph.D. (Assistant Professor) (Assistant Professor)

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© 1996 Springer-Verlag Berlin Heidelberg

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Hromas, R. et al. (1996). Hematopoietic Transcriptional Regulation by the Myeloid Zinc Finger Gene, MZF-1. In: Wolff, L., Perkins, A.S. (eds) Molecular Aspects of Myeloid Stem Cell Development. Current Topics in Microbiology and Immunology, vol 211. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85232-9_16

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  • DOI: https://doi.org/10.1007/978-3-642-85232-9_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85234-3

  • Online ISBN: 978-3-642-85232-9

  • eBook Packages: Springer Book Archive

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