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Multiple System Atrophy

Abstract

MSA is pathologically characterised by selective vulnerability of the striatonigral and olivopontocerebellar systems which may show varying degrees of neurodegeneration and underlie the stratification of this heterogeneous disorder into MSA-P and MSA-C clinical variants, which correlate to the morphological phenotypes of striatonigral degeneration (SND) and olivopontocerebellar atrophy (OPCA). The lesions are not limited to these most consistently and severely affected systems, but may involve many other parts of the central, peripheral and autonomic nervous systems (Wakabayashi et al. 2010; Jellinger 2011b; Ubhi et al. 2011), underpinning the multisystem character of MSA.

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    Kurt Jellinger MD

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    Gregor K. Wenning

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    Alessandra Fanciulli

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Jellinger, K. (2014). Neuropathology. In: Wenning, G., Fanciulli, A. (eds) Multiple System Atrophy. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0687-7_3

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