Abstract
A 39 amino acid peptide consisting of a B-cell epitope of the sperm specific lactate dehydrogenase (LDH-C4) and a promiscuous T-cell epitope of Tetanus toxin (TT) was tested as a contraceptive vaccinogen in female baboons. In a series of three trials significant and reversible suppression of fertility was observed. This synthetic peptide construct is the first sperm antigen proposed for Phase I trials in human subjects.p
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© 1999 Springer Science+Business Media Dordrecht
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Goldberg, E., Herr, J.C. (1999). LDH-C4 as a Contraceptive Vaccine. In: Gupta, S.K. (eds) Reproductive Immunology. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4197-0_33
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DOI: https://doi.org/10.1007/978-94-011-4197-0_33
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