Abstract
The effects of pimozide on sucrose intake were examined, in a two-bottle preference test (sucrose versus water), and in single-bottle tests at five different sucrose concentrations. In the two-bottle test, pimozide dose dependently decreased sucrose intake but increased water intake. In the single-bottle test pimozide decreased sucrose intake at low concentrations but had no effect at high concentrations. The results support a role for dopamine in mediating the rewarding effect of sucrose.
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Towell, A., Muscat, R. & Willner, P. Effects of pimozide on sucrose consumption and preference. Psychopharmacology 92, 262–264 (1987). https://doi.org/10.1007/BF00177926
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DOI: https://doi.org/10.1007/BF00177926