Summary
The effects of sodium bicarbonate and aluminium hydroxide on the absorption and activity of glipizide have been studied in healthy volunteers in two randomized cross-over trials. After an overnight fast, 5 mg glipizide was given either with 150 ml water or with water containing 3.0 g sodium bicarbonate or 1.0 g aluminium hydroxide.
Sodium bicarbonate significantly increased the AUC of plasma glipizide from 0 to 0.5 h, 0 to 1 h, and from 0 to 2 h (six-, four- and twofold, respectively). The time to peak concentration (tmax) fell from 2.5 h during the control phase to 1.0 h during the sodium bicarbonate phase. The absorption half-life (t1/2a), lag time and mean residence time (MRT) were also significantly decreased. No significant change in peak plasma concentration (Cmax), total AUC or elimination half-life (t1/2) was noted. The decremental plasma glucose areas from 0 to 1 h and 0 to 2 h were significantly larger (80% and 50%, respectively) than during the control phase. The maximal decrease in glucose was 50% greater during the sodium bicarbonate phase, and the time to reach it was reduced by 35 min. Aluminium hydroxide had no significant effects on the rate or extent of absorption of glipizide, and the glucose response also remained unaffected.
It is concluded that the concomitant ingestion of sodium bicarbonate and glipizide may result in accelerated absorption of glipizide and an increased effect on glucose. A common dose of aluminium hydroxide did not appear to affect the absorption of glipizide.
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References
Wåhlin-Boll E, Almer L-O, Melander A (1982) Bioavailability, pharmacokinetics and effects of glipizide in type 2 diabetics. Clin Pharmacokinet 7: 363–372
Kradjan WA, Kobayashi KA, Bauer LA, Horn JR, Opheim KE, Wood FJ (1989) Glipizide pharmacokinetics: effects of age, diabetes, and multiple dosing. J Clin Pharmacol 29: 1121–1127
Hartling SG, Faber OK, Wegmann M-L, Wåhlin-Boll E, Melander A (1987) Interaction of ethanol and glipizide in humans. Diabetes Care 10: 683–686
Ikegami H, Shima K, Tanaka A, Tahara Y, Hirota M, Kumahara Y (1986) Interindividual variation in the absorption of glibenclamide in man. Acta Endocrinol 111: 528–532
Melander A, Bitzen P-O, Faber O, Groop L (1989) Sulphonylurea antidiabetic drugs: an update of their clinical pharmacology and rational therapeutic use. Drugs 37: 58–72
Wåhlin-Boll E, Melander A, Sartor G, Schersten B (1980) Influence of food intake on the absorption and effect of glipizide in diabetics and in healthy subjects. Eur J Clin Pharmacol 18: 279–283
Hurwitz A (1977) Antacid therapy and drug kinetics. Clin Pharmacokinet 2: 269–280
Gugler R, Allgayer H (1990) Effects of antacids on the clinical pharmacokinetics of drugs: an update. Clin Pharmacokinet 18: 210–219
Neuvonen PJ, Kivistö KT (1988) Effect of magnesium hydroxide on the absorption of tolfenamic and mefenamic acids. Eur J Clin Pharmacol 35: 495–501
Segre EJ, Sevelius H, Varady J (1974) Effects of antacids on naproxen absorption. N Engl J Med 291: 582–583
Hurwitz A, Schlozman DL (1974) Effects of antacids on gastrointestinal absorption of isoniazid in rat and man. Am Rev Respir Dis 109: 41–47
Verbeeck R, Tjandramaga TB, Mullie A, Verbesselt R, DeSchepper PJ (1979) Effect of aluminium hydroxide on diflunisal absorption. Br J Clin Pharmacol 7: 519–522
Wåhlin-Boll E, Melander A (1979) High-performance liquid chromatographic determination of glipizide and some other sulfonylurea drugs in serum. J Chromatogr 164: 541–546
Emilsson H (1987) High-performance liquid chromatographic determination of glipizide in human plasma and urine. J Chromatogr 421: 319–326
Tuderman V, Klinge E, Lind H (1982) In vitro evaluations of antacid suspensions marketed in Finland. Acta Pharm Fenn 91: 153–173
Marchetti P, Navalesi R (1989) Pharmacokinetic-pharmacodynamic relationships of oral hypoglycaemic agents: an update. Clin Pharmacokinet 16: 100–128
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Kivistö, K.T., Neuvonen, P.J. Differential effects of sodium bicarbonate and aluminium hydroxide on the absorption and activity of glipizide. Eur J Clin Pharmacol 40, 383–386 (1991). https://doi.org/10.1007/BF00265848
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DOI: https://doi.org/10.1007/BF00265848