Abstract
Hospital records of 27 children with osteogenic sarcoma were reviewed in an effort to define the usefulness of skeletal scintigraphy in the initial evaluation and follow-up of their disease. Serial bone scans as well as plain radiographs, linear tomograms, and computed tomograms were evaluated for evidence of bone or lung metastases. Eighteen patients developed lung metastases and three developed bone metastases. Seven patients demonstrated uptake of tracer in lung metastases, however, the lesions were all easily identifiable by radiographic means. All bone metastases were detected by scintigraphy, in one instance prior to radiographic abnormality. In no cases were bone metastases known to occur in the absence of lung metastases. None of the bone scans performed for routine follow-up pruposes resulted in altered therapy for the patient. We propose that skeletal scintigraphy is useful in the initial metastatic work up of osteogenic sarcoma, and may be helpful in some patients with specific indications during their follow-up, but is less valuable when there is no clinical suspicion for bone metastases.
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Cade S (1955) Osteogenic sarcoma. A study based on 133 patients. J R Coll Surg Edinb 1:79
Dahlin DC (1967) Osteogenic sarcoma. In: Bone tumors: general aspects and data on 3987 cases. 2nd edn. Charles C. Thomas, Springfield, pp 156
Edmonson JH, Green SJ, Ivins JC (1980) Methotrexate as adjuvant treatment for primary osteosarcoma (letter). N Engl J Med 303:642
Goldstein H, McNeil B, Zufall E, Jaffe N, Treves S (1980) Changing indications for bone scintigraphy in patients with osteosarcoma. Radiology 135:177
Marcove RC, Hike V, Hajek JV, Levin AG, Hutter RVP (1971) Osteogenic sarcoma in childhood. NY State J Med 71:855
McKillop JH, Etcubanas E, Goris L (1981) The indications for and limitations of bone scintigraphy in osteogenic sarcoma: a review of 55 patients. Cancer 48:1133
McNeil BJ, Cassady JR, Geiser CF, Jaffe N, Traggis D, Treves S (1973) Fluorine — 18 bone scintigraphy in children with osteogenic sarcoma or Ewing's sarcoma. Radiology 109:627
Rosen G, Marcove RC, Caparros B, Nirenberg A, Kosloff C, Huvos A (1979) Primary osteogenic sarcoma — the rationale for preoperative chemotherapy and delayed surgery. Cancer 43:2163
Sim FH, Cupps RE, Dahlin DC, Ivins JC (1972) Postradiation sarcoma of bone. J Bone Joint Surg [Am] 54:1479
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Rees, C.R., Siddiqui, A.R. & duCret, R. The role of bone scintigraphy in osteogenic sarcoma. Skeletal Radiol 15, 365–367 (1986). https://doi.org/10.1007/BF00348863
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DOI: https://doi.org/10.1007/BF00348863