Summary
The study validated the use of urinary toluene diamine (TDA) in postshift samples as an indicator of preceding 8-h exposure to toluene diisocyanate (TDI). Nine workers exposed in TDI-based polyurethane foam production were studied. Their exposure levels varied in 8-h time-averaged samples from 9.5 to 94 μg/m3. The urinary TDA concentrations varied from 6.5 to 31.7μg/g creatinine and they were linearly related to the atmospheric TDI levels. Approximately 20% of TDI is metabolized to diamines but their specificity is remarkable to the extent that by analysis for the 2,4- and 2,6-diamino isomers an idea of the percutaneous absorption may be had.
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Maître, A., Berode, M., Perdrix, A. et al. Biological monitoring of occupational exposure to toluene diisocyanate. Int. Arch Occup Environ Heath 65, 97–100 (1993). https://doi.org/10.1007/BF00405726
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DOI: https://doi.org/10.1007/BF00405726