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Induced healing of aneurysmal bone cysts by demineralized bone particles

A report of two cases

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Abstract

Two cases of induced healing of aneurysmal bone cyst (ABC) following intralesional implantation of a bone paste made of autogeneic bone marrow and allogeneic bone powder are reported. The calcaneum in one case and the superior pubic ramus in the other were blown out by an ABC and would have required extensive surgery. Via a minimal exposure, the cyst was partially evacuated and filled with an admixture of a partially demineralized bone particles with bone marrow. Ossification of the peripheral shell was the first sign of healing and was observed within the first 3 postoperative months. Successful healing was observed in both cases. The rationale underlying this intralesional treatment was that the bone grafting material might reverse ABC expansion by promoting ossification through a bone induction mechanism. The concept of this treatment was to retain the ABC tissue, using its own intrinsic osteogenic potential to promote healing. By triggering intralesional new bone formation, the bone paste represented an effective means to reverse the expanding phase of ABC. The particulated bone allograft was easy to handle and to introduced in an irregular cavity. Moreover, as a complete cyst evacuation was not required, a minimal surgical approach could be used so that the risks and morbidity associated with an extensive approach were reduced. Its use is of particular interest in poorly accessible areas like the pelvis and spine.

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References

  1. American Association of Tissue Banks (1987) Standards for surgical bone banking. AATB, Arlington

    Google Scholar 

  2. Ashton BA, Allen TD, Howlett CR, Eaglesom CC, Hattori A, Owen M (1980) Formation of bone and cartilage by marrow stromal cells in diffusion chambers in vivo. Clin Orthop 151:294–301

    Google Scholar 

  3. Aspenberg P, Lohmander LS, Thorngren KG (1988) Failure of bone induction by bone matrix in adult monkeys. J Bone Joint Surg [Br] 70:625–627

    Google Scholar 

  4. Biesecker JL, Marcove RC, Huvos AG, Mike V (1970) Aneurysmal bone cysts. A clinicopathologic study of 66 cases. Cancer 26:615–625

    Google Scholar 

  5. Campanacci M, Capanna R, Picci P (1986) Unicameral and aneurysmal bone cysts. Clin Orthop 204:25–36

    Google Scholar 

  6. Campanacci M (1990) Aneurysmal bone cyst. In: Campanacci M (ed) Bone and soft tissue tumors. Springer, Berlin Heidelberg New York, pp 725–751

    Google Scholar 

  7. Celeste AJ, Iannazzi JA, Taylor RC, Hewick RM, Rosen V, Wang E, Wozney JM (1990) Identification of transforming growth factor β family members present in bone-inductive protein purified from bovine bone. Proc Natl Acad Sci USA 87:9843–9847

    Google Scholar 

  8. Cook SD, Baffes GC, Wolfe MW, Sampath TK, Rueger DC, Whitecloud III TC (1994) The effect of recombinant human osteogenic protein-1 on healing of large segmental bone defects. J Bone Joint Surg [Am] 76:827–838

    Google Scholar 

  9. Cottalorda J, Bollini G, Panuel M, Scheiner C, Jouve JL, Labriet C, Bouyala JM (1993) Le kyste anéurysmal des os chez l'enfant. Rev Chir Orthop 79:272–280

    Google Scholar 

  10. Dabezies EJ, D'Ambrosia RD, Chuinard RG, Ferguson AB (1982) Aneurysmal bone cyst after fracture: a report of three cases. J Bone Joint Surg [Am] 64:617–621

    Google Scholar 

  11. Dabska M, Buraczewski J (1969) Aneurysmal bone cyst: pathology, clinical course and radiologic appearances. Cancer 23:371–389

    Google Scholar 

  12. DeCristofaro R, Biagini R, Boriani S, Picci P, Rugieri P, Rossi G, Fabbri N, Roversi R (1992) Selective arterial embolization in the treatment of aneurysmal bone cyst and angioma of bone. Skeletal Radiol 21:523–527

    Google Scholar 

  13. Delloye C (1990) The bridging capacity of a cortical bone defect by different bone grafting materials and diaphyseal distraction lengthening. Thesis, Catholic University of Louvain

  14. Delloye C (1993) Current situation and future of tissue banking in orthopaedics. In: Duparc J (ed) Post graduate lectures of European Federation of National Association of Orthopaedics and Traumatology (EFORT). Masson, Paris, pp 161–172

    Google Scholar 

  15. Einhorn TA, Lane JM, Burstein AH, Kopman CR, Vigorita VJ (1984) The healing of segmental bone defects induced by demineralized bone matrix. A radiographic and biomechanical study. J Bone Joint Surg [Am] 66:274–279

    Google Scholar 

  16. European Association of Musculoskeletal Transplantation (1994) Standards for tissue banking and current developments. EAMST, Brussels

    Google Scholar 

  17. Farsetti P, Tudisco C, Pentimalli G, Ippolito E (1990) Aneurysmal bone cyst. Long-term follow-up of 20 cases. Arch Orthop Trauma Surg 109:221–223

    Google Scholar 

  18. Johnson EE, Urist MR, Schmalzried TP, Chotivichit A, Huang HK, Finerman GA (1989) Autogeneic cancellous bone grafts in extensive segmental ulnar defects in dogs. Clin Orthop 243:254–265

    Google Scholar 

  19. Lindholm TS, Nilsson OE, Lindholm TC (1982) Extraskeletal and intraskeletal new bone formation induced by demineralized bone matrix combined with bone marrow cells. Clin Orthop 171:251–255

    Google Scholar 

  20. Malghem J, Maldague B, Esselinckx W, Noel H, De Nayer P, Vincent A (1989) Spontaneous healing of aneurysmal bone cysts. A report of three cases. J Bone Joint Surg [Br] 71:645–650

    Google Scholar 

  21. Mirra J (1989) Aneurysmal bone cyt. In: Mina J (ed) Bone tumors. Lea & Febiger, Philadelphia, pp 1267–1311

    Google Scholar 

  22. Murphy WA, Strecker WB, Schoenecker PL (1982) Trans-catheter embolisation therapy of an ischial aneurysmal bone. J Bone Joint Surg [Br] 64:166–168

    Google Scholar 

  23. Reddi AH, Wientroub S, Muthukumaran M (1987) Biologic principles of bone induction. Orthop Clin N Am 18:207–212

    Google Scholar 

  24. Schwarz N, Schlag G, Thumher M, Eschberger J, Dinges HP, Redi H (1991) Fresh autogeneic, frozen allogeneic and decalcified allogeneic bone grafts in dogs. J Bone Joint Surg [Br] 73:787–790

    Google Scholar 

  25. Scott I, Connell DG, Duncan CP (1986) Regression of aneurysmal bone cyst following open biopsy. J Can Assoc Radiol 37:198–200

    Google Scholar 

  26. Takagi K, Urist MR (1982) The role of bone marrow in bone morphogenetic protein-induced repair of femoral massive diaphyseal defects. Clin Orthop 171:224–231

    Google Scholar 

  27. Urist MR (1965) Bone: formation by autoinduction. Science 150:893–899

    Google Scholar 

  28. Vandersteenhoven JJ, Spector M (1983) Histological investigation of bone induction by demineralized allogeneic bone matrix: a natural biomaterial for osseous reconstruction. J Biomed Mater Res 17:1003–1014

    Google Scholar 

  29. Wilner D (1982) Radiology of bone tumors and allied disorders. Saunders, Philadelphia, pp 1003–1103

    Google Scholar 

  30. Wittbjer J, Palmer B, Rohlin M, Thorngren KG (1983) Osteogenetic activity in composite grafts of demineralized compact bone and marrow. Clin Orthop 173:229–238

    Google Scholar 

  31. Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, Hewick RM, Wang EA (1988) Novel regulators of bone formation: molecular clones and activities. Science 242:1528–1534

    Google Scholar 

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Delloye, C., De Nayer, P., Malghem, J. et al. Induced healing of aneurysmal bone cysts by demineralized bone particles. Arch Orthop Trauma Surg 115, 141–145 (1996). https://doi.org/10.1007/BF00434541

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  • DOI: https://doi.org/10.1007/BF00434541

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