Abstract
The relationships between urinary prostaglandins (PGs)E2 and F2α and the postnatal development of blood pressure and renal concentrating capacity were investigated in 14 pre-term and 32 full term healthy infants. Mean PGE2 and PGF2α excretion was 18.9 and 10.1 ng/h/1.73 m2, respectively, in pre-term infants. In full term infants mean urinary PGE2 was signifincantly lower (13.4 ng/h/1.73 m2) and PGF2α significantly higher (22.2 ng/h/1.73 m2). The decrease of the PGE2/PGF2α ratio (P<0.001) was accompanied by an increase in blood pressure. High PGE2 levels in pre-term infants were inversely correlated with urinary cAMP excretion. A decreasing PGE2/PGF2α ratio in full term infants was associated with increasing urinary osmolality. After intranasal administration of antidiuretic hormone (DDAVP) in 8 full term infants the increase in urinary osmolality and cAMP excretion was accompanied by a drop in PGE2 excretion to less than half the basal values.
These findings suggests that the postnatal changes in urinary PG excretion are associated with a concomittant increase in blood pressure and in the concentrating capacity of the neonatal kidney.
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Joppich, R., Scherer, B. & Weber, P.C. Renal prostaglandins: Relationship to the development of blood pressure and concentrating capacity in pre-term and full term healthy infants. Eur J Pediatr 132, 253–259 (1979). https://doi.org/10.1007/BF00496848
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DOI: https://doi.org/10.1007/BF00496848