Summary
Plasma cimetidine levels were determined in 9 normal subjects after a single oral dose of cimetidine 400 mg under control conditions, 2 h before metoclopramide 20 mg and 2 h after a potent antacid. The bioavailability of cimetidine was not significantly affected by metoclopramide and it was marginally reduced by the antacid.
This is a preview of subscription content, log in via an institution to check access.
References
Gugler R, Brand M, Somogyi A (1981) Impaired cimetidine absorption due to antacids and metoclopramide. Eur J Clin Pharmacol 20: 225–228
Kanto J, Allonen H, Jalonen H, Mantyla R (1981) The effect of metoclopramide and propantheline on the gastrointestinal absorption of cimetidine. Br J Clin Pharmacol 11: 629–631
Steinberg WM, Lewis JH, Katz DM (1982) Antacids inhibit absorption of cimetidine. N Engl J Med 307: 400–404
Normann S, Russell W, Guild R, Doering P, Lopez L (1982) Some effects of Mylanta II and bicarbonate on cimetidine absorption. Gastroenterology 82: 1138
Bodemar G, Norlander B, Walan A (1979) Diminished absorption of cimetidine caused by antacids. Lancet 1: 444–445
Burland WL, Darkin DW, Mills MW (1976) Effect of antacids on absorption of cimetidine. Lancet 2: 965
Randolph WC, Osborne VL, Walkenstein SS, Intoccia AP (1977) High-pressure liquid chromatographic analysis of cimetidine, a histamine H2-receptor antagonist, in blood and urine. J Pharm Sci 66: 1148–1150
Perucca E, Gatti G, Frigo GM, Crema A, Calzetti S, Visintini D (1978) Disposition of sodium valproate in epileptic patients. Br J Clin Pharmacol 5: 495–499
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Barzaghi, N., Crema, F., Mescoli, G. et al. Effects on cimetidine bioavailability of metoclopramide and antacids given two hours apart. Eur J Clin Pharmacol 37, 409–410 (1989). https://doi.org/10.1007/BF00558511
Issue Date:
DOI: https://doi.org/10.1007/BF00558511