Summary
10 healthy volunteers were given 40 mg furosemide p. o. with and without breakfast. The meal reduced the peak level of furosemide and decreased its bioavailability by approximately 30%. A heavy meal given to 5 of the subjects had no further effect. The reduced bioavailability caused a reduction in the diuretic effect.
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References
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Beermann, B., Midskov, C. Reduced bioavailability and effect of furosemide given with food. Eur J Clin Pharmacol 29, 725–727 (1986). https://doi.org/10.1007/BF00615967
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DOI: https://doi.org/10.1007/BF00615967