Skip to main content
SpringerLink
Log in

Meaning of energetic parameters

  • Original Contributions
  • Published:
Basic Research in Cardiology Aims and scope Submit manuscript

Summary

High energy phosphates (HEP: ATP & phosphocreatine (PCr)) are to be considered under qualitative (free energy of hydrolysis) and quantitative (concentration) aspects. Energy charge is also a (normalized) concentration related parameter. Owing to high turnover rates concentration (HEP stores) provides sufficient energy only for 10 to 20 s in the case of interruption of supply. Utilization (without immediate supply) leads to rapid drop of free energy which — owing to the CK reaction — is indicated by rapid drop of PCr and the respective ratios. Critical reduction of free energy appears to be prevented by various protective mechanisms reflected in phenomena of early hypoxic failure, hibernating and stunning.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Gibbs C (1985) The cytoplasmic phosphorylation potential: Its possible role in the control of myocardial respiration and cardiac contractility. J Mol Cell Cardiol 17:727–731

    Google Scholar 

  2. Griese M, Perlitz V, Juengling E, Kammermeier H (1988) Myocardial performance and free energy of ATP-hydrolysis in isolated rat hearts during graded hypoxia reoxygenation and high K+-perfusion. J Mol Cell Cardiol 20:1189–1201

    Google Scholar 

  3. Hoerter JA, Lauer C, Vassort G, Gueron M (1988) Substained function of normoxic hearts depleted in ATP and phosphocreatine a 31P-NMR study. Am J Physiol 255:C192-C201

    Google Scholar 

  4. Kammermeier H (1964) Verhalten von Adenin-Nukleotiden und Kreatinphosphat im Herzmuskel bei funktioneller Erholung nach länger dauernder Asphyxie. Verhandlungen der Deutschen Gesellschaft für Kreislaufforschung 30:206–211

    Google Scholar 

  5. Kammermeier H (1987) Why do cells need phosphocreatine and a phosphocreatine shuttle. J Mol Cell Cardiol 19:115–118

    Google Scholar 

  6. Kammermeier H, Roeb E (1990) Regulation of systolic force and control of free energy of ATP-hydrolysis in hypoxic hearts. J Mol Cell Cardiol 22:707–713

    Google Scholar 

  7. Kammermeier H, Schmidt P, Jüngling E (1982) Free energy change of ATP-hydrolysis: a causal factor of early hypoxic failure of the myocardium? J Mol Cell Cardiol 14:267–277

    Google Scholar 

  8. Neubauer S, Haman BL, Perry SB, Bittl JA, Ingwall JS (1988) Velocity of the creatine kinase reaction decreases in postischemic myocardium A 31P-NMR magnetization transfer study of the isolated ferret heart. Circ Res 63:1–15

    Google Scholar 

  9. Veech RL, Lawson JWR, Cornell NW, Krebs HA (1979) Cytosolic phosphorylation potential. J Biol Chem 254:6538–6547

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Physiology, Medical Faculty RWTH Aachen, Aachen, Germany

    H. Kammermeier

  2. Magnetic Resonance Spectroscopy Group, Department of Cardiothoracic Surgery, National Heart & Lung Institute at Harefield Hospital, UB9 6JH, Harefield, Middlesex, UK

    Anne-Marie L. Seymour

Authors
  1. H. Kammermeier
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Anne-Marie L. Seymour
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kammermeier, H., Seymour, AM.L. Meaning of energetic parameters. Basic Res Cardiol 88, 380–384 (1993). https://doi.org/10.1007/BF00795405

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00795405

Key words

Search

Navigation