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Correlation of ultrasound and renal scintigraphy in children with unilateral hydronephrosis in primary workup

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Abstract

Ultrasound accurately detects hydronephrosis in infants and children, while nuclear medicine techniques quantify relative renal function in addition to characterizing the urodynamic relevance of hydronephrosis. This prospective study was undertaken to examine the relationship between ultrasound morphological findings and relative renal function, quantified with dynamic99mtechnetium mereaptotriacetylglycine imaging, in the initial diagnostic workup of children with unilateral hydronephrosis. The ultrasound grade of hydronephrosis and relative renal function ipsilateral to the hydronephrosis were inversely related, indicating that with more severe hydronephrosis ultrasound fails to estimate the potential reduction of relative kidney function. Because renal function is not necessarily affected by hydronephrosis, renal scintigraphy is indicated to assess the functional status of hydronephrotic kidneys.

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References

  1. Rosendahl H (1990) Ultrasound screening for fetal urinary tract malformations: a prospective study in general population. Eur J Obstet Gynecol Reprod Biol 36: 27–33

    Google Scholar 

  2. Homsy YL, Saad F, Laberge I, Williot P, Pison C (1990) Transitional hydronephrosis of the newborn and infant. J Urol 144: 579–583

    Google Scholar 

  3. Johnson HJ, Gleave M, Coleman GU, Nadel HR, Raffel J, Weckworth PF (1987) Neonatal renomegaly. J Urol 138: 1023–1027

    Google Scholar 

  4. Homsy YL, Williot P, Danais S (1985) Transitional hydronephrosis: fact or fantasy? J Urol 136: 339–341

    Google Scholar 

  5. Grignon A, Faliatrault D, Homsy YL, Robitaille P, Filion R, Boutin H, Leblond R (1986) Ureteropelvic junction stenosis: antenatal ultrasonographic diagnosis, postnatal investigation and follow up. Radiology 160: 649–651

    Google Scholar 

  6. Moneer HK (1988) Megaureter. In: King LR (ed) Urologic surgery in neonates and young infants. Saunders, Philadelphia, pp 155–203

    Google Scholar 

  7. International reflux study committee (1981) Medical versus surgical treatment of primary vesicoureteral reflux. Pediatrics 67: 392–400

    Google Scholar 

  8. Smellie JM, Normand ICS (1986) Experience of follow up of children with urinary tract infection. In: O'Grady F, Brumfitte W (eds) Urinary tract infection. Oxford University Press, London, pp 123–138

    Google Scholar 

  9. Stephens FD (1970) Preliminary follow up study of 101 children with reflux treated conservatively. In: Kincaid-Smith P, Fairley KF (eds) Renal infection and renal scarring, 2nd edn. Mercedes, Melbourne, pp 283–285

    Google Scholar 

  10. Rolleston GL, Shannon FT (1970) Relationship of infantile vesicoureteric reflux to renal damage. BM J 1: 460–463

    Google Scholar 

  11. Dwoskin JY, Perlmutter AD (1973) Vesico-ureteral reflux in children: a computerized review. J Urol 109: 888–890

    Google Scholar 

  12. Gordon I, Dhillon HK, Gatanash H, Peters AM (1991) Antenatal diagnosis of pelvic hydronephrosis: assessment of renal function and drainage as a guide to management. J Nucl Med 32: 1649–1654

    Google Scholar 

  13. Ciofetta G, Gordon I, Piepsz A (1988) Clinical applications of nuclear medicine. Arch Dis Child 63: 321–328

    Google Scholar 

  14. Mena I, Darcourt J (1989) Assessment of renal anatomy and function with radionuclides. In: Massry SG, Glassock RJ (eds) Textbook of nephrology, 2nd edn. Williams and Wilkins, Baltimore, pp 1661–1662

    Google Scholar 

  15. O'Reilly PH (1986) Diuresis renography 8 years later: an update. J Urol 136: 993–999

    Google Scholar 

  16. Grignon A, Filion R, Filiatrault D, Robitaille P, Homsy Y, Boutin H, Leblond R (1986) Urinary tract dilatation in utero: classification and clinical applications. Radiology 160: 645–647

    Google Scholar 

  17. Corteville JE, Gray DL, Crane JP (1991) Congenital hydronephrosis: correlation of fetal ultrasonographic findings with infant outcome. Am J Obstet Gynecol 165: 384–388

    Google Scholar 

  18. Kletscher B, De Badiola F, Gonzalez R (1991) Outcome of hydronephrosis diagnosed antenatally. J Pediatr Surg 26: 455–460

    Google Scholar 

  19. Borre GE, Borre DG, Pereira H, Duval AA, Corona R (1990) New quantified echographic features of normal kidney. Hydronephrosis classification. Roentgenblaetter 43: 519–525

    Google Scholar 

  20. Oberhausen E (1981) Nuklearmedizinische Nierenclearanceuntersuchungen. Radiologe 21: 548–552

    Google Scholar 

  21. Arger PH, Coleman BG, Mintz MC, Snyder HP, Camardese T, Arenson RL, Gabbe SG, Aquino L (1985) Routine fetal genitourinary tract screening. Radiology 156: 485–489

    Google Scholar 

  22. Helin I, Persson PH (1986) Prenatal diagnosis of urinary tract abnormalities by ultrasound. Pediatrics 78: 879–883

    Google Scholar 

  23. Livera LN, Brookfield DSK, Eggington JA, Hawnaur JM (1989) Antenatal ultrasonography to detect fetal renal abnormalities: a prospective screening program. BMJ 298: 1421–1423

    Google Scholar 

  24. Gruenewald SM, Cohen RC, Antico VF, Farlow DC, Cass DT (1990) Diagnosis and treatment of antenatal uropathies. J Paediatr Child Health 26: 142–147

    Google Scholar 

  25. Marshall JL, Johnson ND, De Campo MP (1990) Vesicoureteric reflux in children: prediction with color doppler imaging. Radiology 175: 355–358

    Google Scholar 

  26. Gordon I, Dhillon HK, Peters AM (1991) Antenatal diagnosis of renal pelvic dilatation — the natural history of conservative management. Pediatr Radiol 21: 272–273

    Google Scholar 

  27. Kleiner B, Callen PW, Filly RA (1987) Sonographic analysis of the fetus with ureteropelvic junction obstruction. AJR 148: 359–363

    Google Scholar 

  28. Dowling KJ, Harmon EP, Ortenberg J, Polanco E, Blackwell BE (1988) Ureteropelvic junction obstruction: the effect of pyeloplasty on renal function. J Urol 140: 1227–1230

    Google Scholar 

  29. Hoffman AD (1985) Uroradiology: procedures and anatomy. In: Kelalis PP, King LR, Belman AB (eds) Clinical pediatric urology, 2nd edn., vol 1. Saunders, Philadelphia, pp 93–139

    Google Scholar 

  30. Jafri RA, Britton KE, Nimmon CC, Solanki K, Al-Nahhas A, Bomanji J, Fettich J, Hawkins LA (1988) Technetium-99m-MAG3: a comparison with iodine-123- and iodine-131- orthoiodonippurate in patients with renal disorders. J Nucl Med 29: 141–158

    Google Scholar 

  31. Bubeck B (1990) Technetium-99m-MAG3 für die nuklearmedizinische Nierenfunktionsdiagnostik. Pharmakokinetik and klinische. Anwendung im Vergleich mit radiojodierter Hippursäure. Huber, Bern

    Google Scholar 

  32. Brandau W, Bubeck B, Eisenhut M, Taylor DM (1988) Technetium-99m-labeled renal function and imaging agents. III. Synthesis of 99m-Tc-MAG3 and biodistribution of by-products. Int J Rad Appl Instrum [A] 39: 121–129

    Google Scholar 

  33. Bubeck B, Brandau W, Weber E, Kaelble T, Parekh N, Georgi P (1990) Pharmacokinetics of technetium-99m-MAG3 in humans. J Nucl Med 31: 1285–1293

    Google Scholar 

  34. Snyder WS, Ford MR, Warner GG, Watson SB (1975) Medical internal radiation dose committee publications. J Nucl Med, pamphlet no. 11

  35. Roedler HD, Kaul A, Hine GJ (1978) Internal radiation dose in diagnostic nuclear medicine. Hoffmann, Berlin

    Google Scholar 

  36. Irving HC, Arthur RJ, Thomas DF (1987) Percutaneous nephrostomy in pediatrics. Clin Radiol 38: 245–248

    Google Scholar 

  37. O'Brien WM, Matsumoto AH, Grant EJ, Gibbons MD (1990) Percutaneous nephrostomy in infants. Urology 36: 269–272

    Google Scholar 

  38. Towbin RB (1989) Pediatric interventional procedures in the 1980s. a period of development, growth and acceptance. Radiology 170, 1081–1090

    Google Scholar 

  39. King LR, Hatcher PA (1990) Natural history of fetal and neonatat hydronephrosis. Urology 35: 433–438

    Google Scholar 

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Authors and Affiliations

  1. Division of Nuclear Medicine and Special Biophysics, Department of Radiological Science, UCLA School of Medicine, 10833 Le Conte Avenue, AR-115, 90024-1721, Los Angeles, CA, USA

    Egbert U. Nitzsche, Randall A. Hawkins, Young Choi & Carl K. Hoh

  2. Department of Nuclear Medicine, Albert-Ludwigs-University, School of Medicine, Freiburg, Germany

    Egbert U. Nitzsche & Ernst A. Moser

  3. Department of Pediatrics, Albert-Ludwigs-University, School of Medicine, Freiburg, Germany

    Lothar B. Zimmerhackl

  4. Department of Radiodiagnostics, Albert-Ludwigs-University, School of Medicine, Freiburg, Germany

    Brigitte Stöver & Günther Sigmund

  5. Department of Urology, Albert-Ludwigs-University, School of Medicine, Freiburg, Germany

    Alexander Frankenschmidt

Authors
  1. Egbert U. Nitzsche
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  2. Lothar B. Zimmerhackl
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  3. Randall A. Hawkins
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  4. Brigitte Stöver
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  5. Alexander Frankenschmidt
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  6. Günther Sigmund
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  7. Young Choi
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  8. Carl K. Hoh
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  9. Ernst A. Moser
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Nitzsche, E.U., Zimmerhackl, L.B., Hawkins, R.A. et al. Correlation of ultrasound and renal scintigraphy in children with unilateral hydronephrosis in primary workup. Pediatr Nephrol 7, 138–142 (1993). https://doi.org/10.1007/BF00864377

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  • DOI: https://doi.org/10.1007/BF00864377

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