Abstract
The response to an intraperitoneal (i.p.) parasite challenge was compared with that caused by an oral challenge, in five different strains of mice. The results are consistent with the hypothesis that murine susceptibility to toxoplasmosis is route of challenge-dependent as well as strain-dependent. The phenomenon occurs in both sexes and appears to be a recessive trait. The finding that the susceptibility of C57BL/6j mice to oral or i.p. challenge is almost the reverse of that of LACA mice, and that BALB/c mice are resistant to challenge by either route, offers an excellent laboratory model for studies on susceptibility to toxoplasmosis.
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References
Araujo FG, Williams DM, Grumet FC, Remington JS (1976) Strain-dependent differences in murine susceptibility toToxoplasma. Infect Immun 13:1528–1530
Copeland D, Grove DI (1979) Effects ofToxoplasma gondii (Gleadle strain) on the host-parasite relationship in trichinosis. Int J Parasitol 9:205–211
Dubey JP (1980) Mouse pathogenicity ofToxoplasma gondii isolated from a goat. Am J Vet Res 41:427–429
Dubey JP, Frenkel JK (1973) ExperimentalToxoplasma infection in mice with strains producing oocysts. J Parasitol 59:505–512
Dubey JP, Sharma SP, Juranek DD, Sulzer AJ, Teutsch SM (1981) Characterization ofToxoplasma gondii isolates from an outbreak of toxoplasmosis in Atlanta, Georgia. Am J Vet Res 42:1007–1010
Jacobs L (1974)Toxoplasma gondii: parasitology and transmission. Bull NY Acad Med 50:128–145
Jacobs L, Remington JS, Melton ML (1960) The resistance of the encysted form ofToxoplasma gondii. J Parasitol 46:11–21
Johnson AM, McDonald PJ, Neoh SH (1983a) Monoclonal antibodies toToxoplasma cell membrane surface antigens protect mice from toxoplasmosis. J Protozool 30:351–356
Johnson AM, McDonald PJ, Neoh SH (1983b) Molecular weight analysis of soluble antigens fromToxoplasma gondii. J Parasitol 69:459–464
Mahmoud AAF, Strickland GT, Warren KS (1977) Toxoplasmosis and the host-parasite relationship in murine schistosomiasis mansoni. J Infect Dis 135:408–413
Masihi KN, Werner H (1977) Immunization of NMRI mice against virulentToxoplasma gondii. Differing efficacy of eleven cyst-formingToxoplasma strains. Z. Parasitenkd 54:209–216
Miller NL, Frenkel JK, Dubey JP (1972) Oral infections withToxoplasma cysts and oocysts in felines, other mammals, and in birds. J Parasitol 58:928–937
Mitchell GF, Anders RF, Brown GV, Handman E, Roberts-Thomson IC, Chapman CB, Forsyth KP, Kahl LP, Cruise KM (1982) Analysis of infection characteristics and antiparasitic immune responses in resistant compared with susceptible hosts. Immunol Rev 61:137–188
Siegel S (1956) Nonparametric statistics for the behavioural sciences. Mc Graw-Hill, Tokyo
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Johnson, A.M. Strain-dependent, route of challenge-dependent, murine susceptibility to toxoplasmosis. Z. Parasitenkd. 70, 303–309 (1984). https://doi.org/10.1007/BF00927816
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DOI: https://doi.org/10.1007/BF00927816