Abstract
Kainic acid-induced seizures produced early (2 hr) generalized edema and later (24 and 48 hr) necrotic edema in temporal cortex and hippocampus as measured by specific gravity changes. Mannitol given during the seizure partially protected against the early edema and prevented the necrotic edema indicating early edema may play a role in later brain damage. However, H2O intoxication, causing much greater generalized edema than the kainic acidinduced seizures, caused no necrotic edema in temporal cortex or hippocampus at 48 hr. Thus it appears that mannitol protection against kainic acid-induced brain damage may be by a mechanism in addition to dehydration.
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References
Sano, K., and Malmud, N. 1953. Clinical significance of sclerosis of the cornu ammonis. Arch. Neurol. Psych. 69:40–53.
Fowler, M. 1957. Brain damage after febrile convulsions. Arch. Dis. Child 32:67–76.
Aicardi, J., and Chevrie, J.-J. 1983. Consequences of status epilepticus in infants and children. Adv. Neurol. 34:115–125.
Corsellis, J. A. N., and Bruton, C. J. 1983. Neuropathology of status epilepticus in humans. Adv. Neurol. 34:129–139.
Falconer, M. A., Serafetinides, E. A., and Corsellis, J. A. N. 1964. Etiology and pathogenesis of temporal lobe epilepsy. Arch. Neurol. 10:233–247.
Siesjo, B. K. 1981. Cell damage in the brain: A speculative synthesis. J. Cerebral Blood Flow Met. 1:155–185.
Meldrum, B. S. 1983. Metabolic factors during prolonged seizures and their relation to nerve cell death. Adv. Neurol. 34:261–275.
Delgado-Escueta, A. V., and Bajorek, J. G. 1982. Status epilepticus: Mechanism of brain damage and rational management. Epilepsia 23:S29–41.
Coyle, J. T. 1983. Neurotoxic action of kainic acid. J. Neurochem. 41:1–14.
Ben-Ari, Y. 1985. Limbic seizure and brain damage produced by kainic acid: Mechanisms and relevance to human temporal lobe epilepsy. Neuroscience 14:375–403.
Samson, F. E., Pazdernik, T. L., Cross, R. S., Giesler, M. P., Mewes, K., Nelson, S. R., and McDonough, J. H. 1984. Soman induced changes in brain regional glucose use. Fun. App. Toxicol. 4:S173-S183.
Sperk, G., Lassmann, H., Baran, H., Kish, S. J., Seitelberger, F., and Hornykiewicz, O. 1983. Kainic acid induced seizures: neurochemical and histopathological changes. Neuroscience 10:1301–1315.
Lassmann, H., Petsche, U., Kitz, K., Baran, H., Sperk, G., Seitelberger, F., and Hornykiewicz, O. 1984. The role of brain edema in epileptic brain damage induced by systemic kainic acid injection. Neuroscience 13:691–704.
Barbour, H. G., and Hamilton, W. F. 1924. Blood specific gravity: Its significance and a new method for its determination. Amer. J. Physiol. 69:654–661.
Linderstrøm-Lang, K. 1937. Dilatometric ultra-micro-estimation of peptidase activity. Nature 139:713–714.
Lowry, O. H., and Hunter, T. H. 1945. The determination of serum protein concentration with a gradient tube. J. Biol. Chem. 159:465–474.
Lowry, O. H. 1953. The quantitative histochemistry of the brain. J. Histochem. Cytochem. 1:420–428.
Nelson, S. R., Mantz, M.-L., and Maxwell, J. A. 1971. Use of specific gravity in the measurement of cerebral edema. J. Appl. Physiol. 30:268–271.
Wasterlain, C. G., and Torack, R. M. 1968. Cerebral edema in water intoxication. Arch. Neurol. 19:79–87.
Weast, R. C. 1976. Handbook of Chemistry and Physics, 57th ed., Chemical Rubber Co., Cleveland, Ohio, D-252-253.
Bothe, H.-W., Bodsch, W., Hossmann, K.-A. 1984. Relationship between specific gravity, water content, and serum protein extravasation in various types of vasogenic brain edema. Acta Neuropathol. (Berl.) 64:37–42.
Sztriha, L., Joo, F., Szerdahelyi, P., Lelkes, Z., and Adam, G. 1985. Kainic acid neurotoxicity: Characterization of blood-brain barrier damage. Neurosci. Let. 55:233–237.
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Nelson, S.R., Olson, J.P. Role of early edema in the development of regional seizure-related brain damage. Neurochem Res 12, 561–564 (1987). https://doi.org/10.1007/BF01000241
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DOI: https://doi.org/10.1007/BF01000241