Summary
The entry and persistence of phosphomycin in interstitial tissue fluid (ITF) were studied in 9 patients with normal renal function and 8 patients with varying degrees of renal impairment, all of whom received a single i.v. dose of 30 mg/kg. ITF was obtained from skin blisters produced by suction. The antibiotic followed a two-compartment open kinetic model. In patients with normal renal function, phosphomycin is incorporated rapidly into the ITF reaching a level of 60.4 µg/ml 60 min after administration. There was no statistically significant difference between the elimination rates from serum and ITF. The serum half-life of the slow disposition phase was 1.75 h in patients with normal renal function. There was a linear correlation between the elimination half-life of phosphomycin in serum and ITF in subjects with differing degrees of renal impairment.
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Fernandez Lastra, C., Mariño, E.L., Dominguez-Gil, A. et al. The influence of uremia on the accessibility of phosphomycin into interstitial tissue fluid. Eur J Clin Pharmacol 25, 333–338 (1983). https://doi.org/10.1007/BF01037944
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DOI: https://doi.org/10.1007/BF01037944