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Primary central nervous system involvement of the so called ‘peripheral T-cell lymphoma’. Report of a case and review of the literature

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Abstract

Primary central nervous system (CNS) involvement of non-Hodgkin's lymphoma is uncommon and a vast majority of reported cases are of B-cell origin. We present a 52-year-old woman with primary peripheral T-cell lymphoma of the brain. Immunostaining of paraffin-embedded sections proved tumor cells to be positive for T-cell markers MT1 and UCHL1, and negative for B-cell markers MB1, and 4KB5. Radiotherapy combined with steroid therapy rendered neurologic recovery and complete tumor remission confirmed by computed tomography and magnetic resonance imaging. From a review of documented 19 cases of primary CNS T-cell lymphoma including the present case, this disease is characterized by poor prognosis among CNS lymphomas.

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Authors and Affiliations

  1. Neurosurgical Service, Akita University Hospital, Akita, Japan

    Katsuyoshi Mineura, Jun Sawataishi, Toshio Sasajima & Masayoshi Kowada

  2. Department of Neurosurgery, Nakadori Hospital, Akita, Japan

    Atsushi Sugawara & Kazuo Ebina

Authors
  1. Katsuyoshi Mineura
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  2. Jun Sawataishi
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  3. Toshio Sasajima
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  4. Masayoshi Kowada
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  5. Atsushi Sugawara
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  6. Kazuo Ebina
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Mineura, K., Sawataishi, J., Sasajima, T. et al. Primary central nervous system involvement of the so called ‘peripheral T-cell lymphoma’. Report of a case and review of the literature. J Neuro-Oncol 16, 235–242 (1993). https://doi.org/10.1007/BF01057040

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