Abstract
Cimetidine in a dosage of 1000 mg daily (200 mg t.i.d. plus 400 mg nocte) reduced the absorption of protein-bound cobalamin by peptic ulcer patients and normal subjects. However, cimetidine in a dosage of 400 mg at night had no significant effect, nor did tripotassium dicitratobismuthate in a dosage of 480 mg daily. Thus long-term administration of 400 mg cimetidine at night will not produce cobalamin deficiency in man.
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Streeter, A.M., Goulston, K.J., Bathur, F.A. et al. Cimetidine and malabsorption of cobalamin. Digest Dis Sci 27, 13–16 (1982). https://doi.org/10.1007/BF01308115
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DOI: https://doi.org/10.1007/BF01308115