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Estrogens, bone loss and preservation

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References

  1. Hammond CB, Maxson WS. Current status of estrogen therapy for the menopause. Fertil Steril 1982; 37: 5–25.

    PubMed  Google Scholar 

  2. Maschak CA, Lobo RA, Dozono-Takono R et al. Comparison of pharmacodynamic properties of various oestrogen formulations. Am J Obstet Gynecol 1982; 144: 511–18.

    PubMed  Google Scholar 

  3. Hammond CB, Maxson WS. Estrogen replacement therapy. Clin Obstet Gynecol 1986; 29: 407–30.

    PubMed  Google Scholar 

  4. Neumann F. The physiological action of progesterone and the pharmacological effects of progestogens. A short review. Postgrad Med 1978; 54: 11–24.

    Google Scholar 

  5. Bloom RA, Laws JW. Humeral cortical thickness as an index of osteoporosis in women. Br J Radiol 1970; 43: 522–7.

    PubMed  Google Scholar 

  6. Cann CE, Genant HK, Kolb FO, Ettinger B. Quantitative computed tomography for prediction of vertebral fracture risk. Bone 1985; 6: 1–7.

    PubMed  Google Scholar 

  7. Cohn SH, Aloia JF, Vaswani AN, Zanzi I, Vestsky D, Ellis KJ. Age and sex related changes in bone mass by neutron activation. In: Menczel J et al., eds. Osteoporosis. Chichester: Wiley, 1982; 33–43.

    Google Scholar 

  8. Davis ME, Lanzl LH, Cox AB. Detection, prevention and retardation of postmenopausal osteoporosis. Obstet Gynecol 1970; 36: 187–98.

    PubMed  Google Scholar 

  9. Garn SM. The phenomenon of bone formation and bone loss. In: Deluca HF et al., eds. Osteoporosis, recent advances in pathogenesis and treatment. Baltimore: University Park Press, 1981; 1–16.

    Google Scholar 

  10. Garn SM, Rohmann Cg, Wagner B. Bone loss as a general phenomenon in man. Fed Proc 1967; 26: 1729–36.

    PubMed  Google Scholar 

  11. Jasani C, Nordin BEC, Smith DA, Swanson I. Spinal osteoporosis and the menopause. Proc R Soc Med 1965; 58: 441–4.

    PubMed  Google Scholar 

  12. Krolner B, Nielsen SP. Bone mineral content of the lumbar spine in normal and osteoporotic women: cross-sectional and longitudinal studies. Clin Sci 1982; 62: 329–36.

    Google Scholar 

  13. Lindsay R. Osteoporosis and its relationship to estrogen. Contemp Obstet Gynecol 1984; 63: 201–24.

    Google Scholar 

  14. Madsen M. Vertebral and peripheral bone mineral content by photon absorptionmetry. Invest Radiol 1977; 12: 185–8.

    PubMed  Google Scholar 

  15. Mazess RB. Advances in total body and regional bone mineral by dual-photon absorptiometry. In: Menczel J et al., eds. Osteoporosis. Chichester: Wiley, 1982; 80–6.

    Google Scholar 

  16. Maziere B, Kuntz D, Dughesnay M. In vivo analysis of bone calcium by local neutron activation of the hand in postmenopausal osteoporosis. In: Menczel J et al., eds. Osteoporosis. Chichester: Wiley 1982; 117–25.

    Google Scholar 

  17. Meema HE. Cortical bone atrophy and osteoporosis as a manifestation of aging. AJR 1963; 89: 1287–95.

    Google Scholar 

  18. Meema HE. Menopausal and aging changes in muscle mass and bone mineral content. J Bone Joint Surg 1966; 48A: 1138–44.

    Google Scholar 

  19. Nordin BEC, MacGregor J, Smith DA. The incidence of osteoporosis in normal women: its relation to age and the menopause. Q J Med 1966; 137: 25–38.

    Google Scholar 

  20. Solomon L. Bone density in aging Caucasian and African populations. Lancet 1979; i: 1326–30.

    Google Scholar 

  21. Albright F, Bloomberg F, Smith PH. Postmenopausal osteoporosis. Trans Assoc Am Physicians 1940; 55: 298–305.

    Google Scholar 

  22. Albright F, Reifenstein EC Jr. Metabolic bone disease: osteoporosis. In: Albright F, Reifenstein EC, eds., Parathyroid glands and metabolic bone disease. Baltimore: Williams and Wilkins, 1948; 145–204.

    Google Scholar 

  23. Arnold JS, Bartley MH, Tont SA, Jenkins DP. Skeletal changes in aging and disease. Clin Orthop Rel Res 1966; 49: 17–38.

    Google Scholar 

  24. Leichter I, Weinreb A, Hazan G et al. The effect of age and sex on bone density, bone mineral content and cortical index. Clin Orthop Rel Res 1981; 156: 232–39.

    Google Scholar 

  25. Riggs BL, Wahner HW, Dunn WL, Mazess RB, Offord KP, Melton LJ III. Differential changes in bone mineral density of the appendicular and axial skeleton with aging: relationship to spinal osteoporosis. J Clin Invest 1981; 67: 328–35.

    PubMed  Google Scholar 

  26. Trotter M, Hixon BB. Sequential changes in weight, density and percentage weight of human skeletons from an early fetal period through old age. Anat Rec 1974; 179: 1–8.

    PubMed  Google Scholar 

  27. Stevenson JC, Lee B, Devenport M, Cust MP, Ganger KF. Determinants of bone density in normal women: risk factors for future osteoporosis? Br Med J 1989; 298: 924–28

    Google Scholar 

  28. Lindsay R, Cosman F, Herrington B, Himmelstein (in preparation.)

  29. Slemenda C, Hui SL, Longcope C, Johnston CC. Sex steroids and bone mass; a study of changes about the time of the menopause. J Clin Invest 1987; 80: 1261–9.

    PubMed  Google Scholar 

  30. Lindsay R, Coutts JRT, Hart DM. Endogenous oestrogen and bone loss following oophorectomy. Calcif Tissue Res 1977; 22: 213–16.

    PubMed  Google Scholar 

  31. Heaney RP, Recker RR, Saville PD. Calcium balance and calcium requirements in middle-aged women. Am J Clin Nutr 1977; 30: 1603–11.

    PubMed  Google Scholar 

  32. Heaney RP, Becker RR, Saville PD. Menopausal changes in calcium balance performance. J Lab Clin Med 1978; 92: 953–63.

    PubMed  Google Scholar 

  33. Heaney RP, Recker RR, Saville PD. Menopausal changes in bone remodelling. J Lab Clin Med 1978; 92: 964–70.

    PubMed  Google Scholar 

  34. Fogelman I, Poser JW, Smith ML, Hart DM, Bevan JA. Alterations in skeletal metabolism following oophorectomy. In: Christiansen C et al., eds. Osteoporosis. Glostrup, Denmark: Aalborg Stiftsbogtrykkeri, 1984; 519–22.

    Google Scholar 

  35. Aitken JM, Hart DM, Anderson JB, Lindsay R, Smith DA. Osteoporosis after oophorectomy for non-malignant disease. Br Med J 1973; i: 325–8.

    Google Scholar 

  36. Parfitt AM. Quantum concept of bone remodeling and turnover: implications for the pathogenesis of osteoporosis. Calcif Tissue Int 1979; 28: 1–5.

    PubMed  Google Scholar 

  37. Dempster DW, Shane E, Horbert WS, Lindsay R. A simple method for correlative light and scanning electron microscopy of human iliac crest bone biopsies: qualitative observations in normal and osteoporotic subjects. J Bone Min Res 1986; 1: 15–21.

    Google Scholar 

  38. Jensen PB, Jensen J, Riis BJ, Rodbro P, Strom V, Christiansen C. Climacteric symptoms after oral and percutaneous hormone replacement therapy. Maturitas 1987; 9: 207–15.

    PubMed  Google Scholar 

  39. Steingold KA, Laufer L, Chetkowski RJ et al. Treatment of hot flushes with transdermal estradiol administration. J Clin Endocrinol Metab 1985; 61: 627–632.

    PubMed  Google Scholar 

  40. Punnonen R, Rauramo L. The effect of long-term oral oestriol succinate therapy on the skin of castrated women. Ann Chir Gynaecol 1977; 66: 214–15.

    PubMed  Google Scholar 

  41. Campbell S, Whitehead M. Oestrogen therapy and the menopausal syndrome. Clin Obstet Gynecol 1977; 4: 31–47.

    Google Scholar 

  42. Weiss NS, Ure CL, Ballard JH, Williams AR, Daling JR. Decreased risk of fractures of the hip and lower forearm with postmenopausal use of estrogen. N Engl J Med 1980; 303: 1195–8.

    PubMed  Google Scholar 

  43. Lindsay R, Hart DM, Forrest G, Baird C. Prevention of spinal osteoporosis in oophorectomised women. Lancet 1980; ii: 1151–4.

    Google Scholar 

  44. Ettinger B, Genant HK, Cann CE. Long-term estrogen replacement therapy prevents bone loss and fractures. Ann Intern Med 1985; 102: 319–24.

    PubMed  Google Scholar 

  45. Bush TL, Barrett-Connor E, Cowan LD et al. Cardiovascular mortality and noncontraceptive use of estrogen in women: results from the Lipid Research Clinics program follow-up study. Circulation 1987; 75: 1102–9.

    PubMed  Google Scholar 

  46. Ross RK, Paganini-Hill A, Mach TM. Menopausal oestrogen therapy and protection from death from ischaemic heart disease. Lancet 1981; i: 858–60.

    Google Scholar 

  47. Nachtigall LE, Nachtigall RH, Nachtigall RD. Estrogen replacement therapy. II. A prospective study in the relationship to carcinoma and cardiovascular and metabolic problems. Obstet Gynecol 1979; 54: 74–79.

    PubMed  Google Scholar 

  48. Morrison JC, Martin DC, Blair RA et al. The use of medroxypro-gesterone acetate for relief of climacteric symptoms. Am J Obstet Gynecol 1980; 138: 99–104.

    PubMed  Google Scholar 

  49. Lindsay R, Hart DM, Purdie D, Ferguson MM, Clark AS, Kraszewski A. Comparative effects of oestrogen and a progestogen on bone loss in postmenopausal women. Clin Sci 1978; 54: 193–5.

    Google Scholar 

  50. Abdalla HI, Hart DM, Lindsay R, Leggate I, Hooke A. Prevention of bone mineral loss in postmenopausal women by norethisterone. Obstet Gynecol 1985; 66: 789–92.

    PubMed  Google Scholar 

  51. Christiansen C, Christiensen MS, McNair P, Hagen C, Stocklund K-E, Transbol I. Prevention of early postmenopausal bone loss: controlled 2-year study in 315 normal females. Eur J Clin Invest 1980; 10: 273–9.

    PubMed  Google Scholar 

  52. Christiansen C, Christensen MS, Transbol I. Bone mass in postmenopausal women after withdrawal of oestrogen/gestagen replacement therapy. Lancet 1981; i: 459–61.

    Google Scholar 

  53. Lindsay R, Aitken JM, Anderson JB, Hart DMM, MacDonald EB, Clarke AC. Long-term prevention of postmenopausal osteoporosis by oestrogen. Lancet 1976; i: 1038–40.

    Google Scholar 

  54. Christiansen C, Christensen MS, McNair P, Hagen C, Stocklund KE, Transbol I. Prevention of early postmenopausal bone loss. Controlled 2-year study in 315 normal females. Eur J Clin Invest 1980; 10: 273–9.

    PubMed  Google Scholar 

  55. Recker RR, Saville PD, Heaney RP. The effect of estrogens and calcium carbonate on bone loss in postmenopausal women. Ann Intern Med 1977; 87: 649–55.

    PubMed  Google Scholar 

  56. Horsman A, Gallagher JC, Simpson M, Nordin BEC. Prospective trial of estrogen and calcium in postmenopausal women. Br Med J 1977; ii: 789–92.

    Google Scholar 

  57. Riis BJ, Thomsen K, Strom V, Christiansen C. The effect of percutaneous estradiol and natural progesterone on postmenopausal bone loss. Am J Obstet Gynecol 1987; 156: 61–5.

    PubMed  Google Scholar 

  58. Christiansen C, Riis BJ. 17 Estradiol and Cortinuous norethisterone: a unique treatment for established osteoporosis in elderly women. J Clin Endocrinol Metab 1990; in press.

  59. Quigley MET, Martin PL, Burnier AM, Brooks P. Estrogen therapy arrests bone loss in elderly women. Am J Obstet Gynecol 1987; 156: 1516–23.

    PubMed  Google Scholar 

  60. Nachtigall LE, Nachtigall RH, Nachtigall RD. Estrogen replacement therapy. I. A 10-year prospective study in the relationship to osteoporosis. Obstet Gynecol 1979; 53: 277.

    PubMed  Google Scholar 

  61. Lindsay R, Tohme J. Estrogen treatment of patients with established postmenopausal osteoporosis. Obstet Gynecol 1990; 76: 1–6.

    PubMed  Google Scholar 

  62. Horsman A, Jones M, Francis R, Nordin BEC. The effect of estrogen dose on postmenopausal bone loss. N Engl J Med 1983; 309: 1405–7.

    PubMed  Google Scholar 

  63. Riis BJ, Jensen J, Christiansen C. Cyproterone acetate, an alternative gestagen in postmenopausal oestrogen/gestagen therapy. Clin Endocrinol 1987; 26: 327–34.

    Google Scholar 

  64. Christensen MS, Hagen C, Christiansen C, Transbol I. Doseresponse evaluation of cyclic estrogen/gestagen in postmenopausal women. Placebo-controlled trial of its gynecologic and metabolic actions. Am J Obstet Gynecoll 1982; 144: 873–9.

    Google Scholar 

  65. Lindsay R, Hart CM, Clarke DM. The minimum effective dose of estrogen for prevention of postmenopausal bone loss. Obstet Gynecol 1983; 63: 759–63.

    Google Scholar 

  66. Gotfredsen A, Nilas L, Riis BJ, Thomsen K, Christiansen C. in early Bone changes occurring spontaneously and caused by oestrogen postmenopausal women: a local or generalized phenomenon? Br Med J 1986; 292: 1098–100.

    Google Scholar 

  67. Riis BJ, Christiansen C. Measurement of spinal or peripheral bone mass to estimate early postmenopausal bone loss? Am J Med 1988; 84: 646–53.

    PubMed  Google Scholar 

  68. Stevenson JC, Banks LM, Spinks TJ et al. Regional and total skeletal measurements in the early postmenopause. J Clin Invest 1987; 80: 258–62.

    PubMed  Google Scholar 

  69. Lindsay R, Hart DM, MacLean A, Clark AC, Kraszewski A, Garwood J. Bone response to termination of oestrogen treatment. Lancet 1978; i: 1325–7.

    Google Scholar 

  70. Hutchinson TA, Polansky SM, Feinstein AR. Post-menopausal oestrogen protects against factures of hip and distal radius. A case-control study. Lancet 1979; ii: 705–9.

    Google Scholar 

  71. Kreiger N, Kelsey JL, Holford TR, O'Connor T. An epidemiologic study of hip fractures in postmenopausal women. Am J Epidemiol 1982; 116: 141–8.

    PubMed  Google Scholar 

  72. Paganini-Hill A, Ross RK, Gerkins VR, Henderson BE, Arthur M, Mack TM. Menopausal estrogen therapy and hip fractures. Ann Intern Med 1981; 95: 28–31.

    PubMed  Google Scholar 

  73. Kiel DP, Felson DT, Anderson JJ, Wilson PWF, Moskowvitz MA. Hip fracture and the use of estrogens in postmenopausal women. The Framingham study. N Engl J Med 1987; 317: 1169–74.

    PubMed  Google Scholar 

  74. Nilas L, Christiansen C, Rodbro P. Calcium supplementation and postmenopausal bone loss. Br Med J 1984; 289: 1103–6.

    Google Scholar 

  75. Riis B, Thomsen K, Christiansen C. Does calcium supplementation prevent postmenopausal bone loss; a double-blind, controlled clinical study. N Engl J Med 1987; 316: 173–7.

    PubMed  Google Scholar 

  76. Ettinger B, Genant HK, Cann CE. Postmenopausal bone loss is prevented by treatment with low-dosage estrogen with calcium.Ann Intern Med 1987; 106: 40.

    PubMed  Google Scholar 

  77. Riis BJ, Nilas L, Christiansen C. Does calcium potentiate the effect of estrogen therapy on postmenopausal bone loss? Bone Miner 1987; 2: 1.

    PubMed  Google Scholar 

  78. Stevenson JC, Abeyasekera G, Hillyard CJ. Regulation of calcium-regulating hormones by exogenous sex steroids in early postmenopause. Eur J Clin Invest 1983; 13: 481–7.

    PubMed  Google Scholar 

  79. Greenberg C, Kirkreja SC, Bowser EN, Hargis GK, Henderson WT, Williams GA. Effect of estradiol and progesterone on calcium secretion. Endocrinology 1990; 118: 2594–8.

    Google Scholar 

  80. Heaney RP. A unified concept of osteoporosis. Am J Med 1965; 39: 377–80.

    Google Scholar 

  81. Komm BS, Terpening CM, Benz DJ. Estrogen binding, receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells. Science 1988; 241: 81–4.

    PubMed  Google Scholar 

  82. Erikssen EF, Colvard DS, Berg NJ. Evidence of estrogen receptors in normal human osteoblast-like cells. Science 1988; 241: 84–6.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Clinical Chemistry, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark

    C. Christiansen

  2. Regional Bone Center and Department of Internal Medicine, Helen Hayes Hospital, West Haverstraw, New York

    R. Lindsay (Chief)

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  1. C. Christiansen
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  2. R. Lindsay
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Christiansen, C., Lindsay, R. Estrogens, bone loss and preservation. Osteoporosis Int 1, 7–13 (1990). https://doi.org/10.1007/BF01880410

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