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Correlation of serum aspirin esterase activity and half-life of Salicylic acid

  • Immunosuppression and Inflammation
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Abstract

An inverse correlation was found between the serum aspirin esterase activity in human subjects and the biological half-life of salicylic acid in serum and a direct relationship between the values of the elimination rate constant and the activity of this enzyme. The rate of acetylsalicylic acid breakdown may be one of the factors which influences the biological half-like of salicylates in the organism and may participate also in determining the individual response to the administered drug.

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Authors and Affiliations

  1. Research Institute of Rheumatic Diseases, Piešt'any, Czechoslovakia

    K. Trnavský & M. Zachar

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  1. K. Trnavský
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  2. M. Zachar
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Trnavský, K., Zachar, M. Correlation of serum aspirin esterase activity and half-life of Salicylic acid. Agents and Actions 5, 549–552 (1975). https://doi.org/10.1007/BF01972693

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  • DOI: https://doi.org/10.1007/BF01972693

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