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Control of hyperoxaluria with large doses of pyridoxine in patients with kidney stones

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Abstract

Pyridoxine in doses of 250–500 mg daily by mouth was administered to 12 patients suffering from recurrent calcium oxalate renal calculi and idiopathic hyperoxaluria. This therapy decreased urinary oxalate excretion significantly (p<0.025) during up to 18 months of treatment. In that period eight patients showed no evidence of active stone disease; three showed slight increase in the size of their old stone(s) and one patient formed one new stone. None of these patients developed any significant complications of the therapy. These findings support the view that pyridoxine in pharmacological doses is useful in the control of elevated urinary oxalate excretion in patients with recurrent renal oxalate calculi.

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Authors and Affiliations

  1. Department of Medicine, Toronto Western Hospital, University of Toronto, Canada

    A. Mitwalli, A. Ayiomamitis, L. Grass & D. G. Oreopoulos

  2. Metabolic-Renal Laboratory, Toronto Western Hospital, University of Toronto, Canada

    A. Mitwalli, A. Ayiomamitis, L. Grass & D. G. Oreopoulos

Authors
  1. A. Mitwalli
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  2. A. Ayiomamitis
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  3. L. Grass
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  4. D. G. Oreopoulos
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Mitwalli, A., Ayiomamitis, A., Grass, L. et al. Control of hyperoxaluria with large doses of pyridoxine in patients with kidney stones. International Urology and Nephrology 20, 353–359 (1988). https://doi.org/10.1007/BF02549567

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  • DOI: https://doi.org/10.1007/BF02549567

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