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Diabetic Vasculopathy: Macro and Microvascular Injury

  • Wound Healing and Tissue Repair (C Yates and R Mota, Section Editors)
  • Published:
Current Pathobiology Reports

Abstract

Purpose of Review

Diabetes is a common and prevalent medical condition as it affects many lives around the globe. Specifically, type-2 diabetes (T2D) is characterized by chronic systemic inflammation alongside hyperglycemia and insulin resistance in the body, which can result in atherosclerotic legion formation in the arteries and thus progression of related conditions called diabetic vasculopathies. T2D patients are especially at risk for vascular injury; adjunct in many of these patients, their cholesterol and triglyceride levels reach dangerously high levels and accumulate in the lumen of their vascular system.

Recent Findings

Microvascular and macrovascular vasculopathies as complications of diabetes can accentuate the onset of organ illnesses; thus, it is imperative that research efforts help identify more effective methods for prevention and diagnosis of early vascular injuries. Current research into vasculopathy identification/treatment will aid in the amelioration of diabetes-related symptoms and thus reduce the large number of deaths that this disease accounts annually.

Summary

This review aims to showcase the evolution and effects of diabetic vasculopathy from development to clinical disease as macrovascular and microvascular complications with a concerted reference to sex-specific disease progression as well.

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Funding

Supported by the Collaborative Research Travel Grant (Burroughs Wellcome Fund) to RIM. EMB is a KL2 scholar partially supported by the UNC Clinical and Translational Science Award-K12 Scholars Program (KL2TR002490), the National Heart, Lung, and Blood Institute (K01HL145354)m and by the UNC-NORC Pilot & Feasibility Grant (P30DK056350).

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  1. Department of Surgery, Division of Vascular Surgery, University of North Carolina at Chapel Hill, 2102 Marsico Hall, 125 Mason Farm Rd., Chapel Hill, NC, 27599, USA

    Roberto I. Mota, Samuel E. Morgan & Edward M. Bahnson

  2. Center for Nanotechnology in Drug Delivery, University of North Carolina at Chapel Hill, 2102 Marsico Hall, 125 Mason Farm Rd., Chapel Hill, NC, 27599, USA

    Roberto I. Mota, Samuel E. Morgan & Edward M. Bahnson

  3. McAllister Heart Institute, University of North Carolina at Chapel Hill, 2102 Marsico Hall, 125 Mason Farm Rd., Chapel Hill, NC, 27599, USA

    Roberto I. Mota & Edward M. Bahnson

  4. Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, 2102 Marsico Hall, 125 Mason Farm Rd., Chapel Hill, NC, 27599, USA

    Edward M. Bahnson

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Dr. Mota reports grants from Burroughs Wellcome Fund, during the conduct of the study.

Mr. Samuel Morgan has nothing to disclose.

Dr. Bahnson reports grants from NIH, during the conduct of the study.

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Mota, R.I., Morgan, S.E. & Bahnson, E.M. Diabetic Vasculopathy: Macro and Microvascular Injury. Curr Pathobiol Rep 8, 1–14 (2020). https://doi.org/10.1007/s40139-020-00205-x

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