Abstract
A one year old boy was found to have a large tumor encompassing the pineal region and extending towards the third and lateral ventricles and quadrigeminal plate. The tumor was composed mostly of small, undifferentiated cells. Some small cells were arranged in Flexner-Wintersteiner rosettes and a few displayed fleurettes. The tumor contained immature cartilage and skeletal muscle and numerous clusters of pigmented epithelial-like cells which, histologically, resembled those found in melanotic neuroectodermal tumors of infancy (retinal anlage tumors) and retinal or ciliary epithelium. Immunologic stains demonstrated neurofilaments, synaptophysin and retinal S-antigen in some of the small cells and transthyretin in some of the epithelial-like cells. The findings indicate that certain primary pineal parenchymal tumors have features in common with tumors of the ocular medullary epithelium.
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References
Russell DS, Rubinstein LJ: Pathology of tumors of the nervous system. 3rd ed. The Williams and Wilkins Co., Baltimore, MD, 1971
DeGirolami U, Schmidek H: Clinicopathological study of 53 tumors of the pineal region. J Neurosurg 39: 455–462, 1973
Donat JF, Okazaki H, Gomez MR, Reagan TJ, Baker HL, Laws ER: Pineal tumors: a 53 year experience. Arch Neurol 35: 736–740, 1978
Banerjee AK, Kak VK: Pineoblastoma with spontaneous intra and extracranial metastases. J Path 114: 9–12, 1974
Borit A, Blackwood W: Pineocytoma with astrocytomatons differentiation. J Neuropathol Exp Neurol 38: 253–258, 1979
Collins VP: Pineocytoma with neuronal differentiation demonstrated immunocytochemically. Acta Path Microbiol Immunol Scand 95: 113–117, 1987
Herrick MK, Rubinstein LJ: The cytological differentiating potential of pineal parenchymal neoplasms (true pinealomas). A clinicopathological study of 28 tumours. Brain 102: 289–320, 1979
Schmidbauer M, Budka H, Pilz P: Neuroepithelial and ectomesenchymal differentiation in a primitive pineal tumor (‘pineal anlage tumor’). Clin Neuropathol 8: 7–10, 1989
Sobel RA, Trice JE, Nielsen SL, Ellis WG: Pineoblastoma with ganglionic and glial differentiation. Acta Neuropathol 55: 243–246, 1981
Stefanko SZ, Manschot WA: Pineoblastoma with retinoblastomatous differentiation. Brain 102: 321–332, 1979
Trojanowski JO, Tascos NA, Rorke LB: Malignant pineocytoma with prominent papillary features. Cancer 50: 1789–1793, 1982
Miettinen M: Synaptophysin and neurofilament proteins as markers for neuroendocrine tumors. Arch Pathol Lab Med 111: 813–818, 1987
Beneski DA, Donoso LA, Edelberg KE, Magargal LE, Folberg R, Merryman C: Human retinal S-antigen: isolation, purification and characterization. Invest Ophthalmol Vis Sci 25: 686–690, 1984
Donoso LA, Merryman CF, Edelberg KE, Naids R, Kalsow C: S-antigen in the developing retina and pineal gland: a monoclonal antibody study. Invest Ophthalmol Vis Sci 25: 561–567, 1985a
Perentes E, Rubinstein LJ, Herman MM, Donoso LA: S-Antigen immunoreactivity in human pineal glands and pineal parenchymal tumors. A monoclonal antibody study. Acta Neuropathol (Berl) 71: 224–227, 1986
Korf H-W, Klein DC, Zigler JS, Gery I, Schachenmayr W: S-antigen-like immunoreactivity in a human pineocytoma. Acta Neuropathol (Berl) 69: 165–167, 1986
Donoso LA, Folberg R, Arbizo V: Retinal S-antigen and retinoblastoma: a monoclonal antibody histopathologic study. Arch Ophthalmol 103: 855–857, 1985c
Bonnin JM, Perentes E: Retinal S-antigen immunoreactivity in medulloblastomas. Acta Neuropathol 76: 204–207, 1988
Best PV: A medulloblastoma-like tumour with melanin formation. J Path 110: 109–111, 1973
Herbert J, Wilcox JN, Pham K-TC, Fremeau RT Jr, Zeviani M, Dwork A, Soprano DR, Makover A, Goodman DS, Zimmerman EA, Roberts JL, Schon EA: Transthyretin: a choroid plexus-specific transport protein in human brain. Neurology 36: 900–911, 1986
Martone RL, Herbert J, Dwork A, Schon EA: Transthyretin is synthesized in the mammalian eye. Biochem Biophys Res Comm 151(2): 905–912, 1988
Cavallaro T, Dwork AJ, Martone RL, Schon EA, Herbert J: Retinal pigment epithelium is the unique site of transthyretin (TTR) synthesis in rat eye. (Abstr) J Neuropathol Exp Neurol 47: 363, 1988
Andersen SR: Differentiation features in some retinal tumors and in dysplastic retinal conditions. Amer J Ophthalmol 71: 231–241, 1971
Broughton WL, Zimmerman LE: A clinicopathologic study of 56 cases of intraocular medulloepitheliomas. Amer J Ophthalmol 85: 407–418, 1978
Reese A: Tumors of the eye. Harper and Row, Hagerstown, MD, 1976, p66
Bader JL, Meadows AT, Zimmerman LE, Rorke LB, Voute PA, Champion LAA, Miller RW: Bilateral retinoblastoma with ectopic intracranial retinoblastoma: trilateral retinoblastoma. Cancer Gen and Cytogen 5: 203–213, 1982
Johnson DL, Chandra R, Fisher WS, Hammock MK, McKeown CA: Trilateral retinoblastoma: ocular and pineal retinoblastomas. J Neurosurg 63: 367–370, 1985
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Raisanen, J., Vogel, H. & Horoupian, D.S. Primitive pineal tumor with retinoblastomatous and retinal/ciliary epithelial differentiation: an immunohistochemical study. J Neuro-Oncol 9, 165–170 (1990). https://doi.org/10.1007/BF02427838
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DOI: https://doi.org/10.1007/BF02427838