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Hostaflavanol A, a new anti-inflammatory and antioxidant activities flavanol from the flowers of Hosta plantaginea

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Abstract

A new flavan-3-ol glycoside, hostaflavanol A (1) along with two related known ones, including dihydrokaempferol (2) and naringnin (3) were isolated from the 80% ethanol extract of Hosta plantaginea flowers. Their structures were elucidated on the basis of chemical and spectral evidence, as well as by comparison with literature data. To the best our knowledge, compounds 2 and 3 were characterized for the first time from the Liliaceae family and genus Hosta, respectively. The anti-inflammatory activity against cyclooxygenases (COX-1 and COX-2) in vitro results revealed that compounds 1‒3 exhibited significant or moderate COX-1 and moderate COX-2 inhibitory effects with IC50 values of 23.7 ± 1.8, 31.6 ± 1.6, and 61.3 ± 3.1 μM for COX-1, as well as 46.7 ± 3.1, 71.2 ± 3.5, and 115.7 ± 6.5 μM for COX-2, respectively. Furthermore, the antioxidant activity of compounds 1‒3 was also measured by the DPPH method, 1‒3 exhibited significant or moderate antioxidant activities with IC50 values of 112.7 ± 3.8, 46.6 ± 1.3, and 82.4 ± 2.4 μM, respectively.

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Acknowledgements

This work was financially supported by the National Natural Science Foundation of China (NSFC) (no. 81503357), the Natural Science Foundation of Jiangxi Province (nos. 20171BBH80026 and 20192BAB215059), and the Science and Technology Project of Jiangxi Provincial Department of Education (no. GJJ180272).

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  1. These authors contributed equally: Li Yang, Yi-min Lin

Authors and Affiliations

  1. Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, China

    Li Yang, Yu Li, Xiao-tong Xie, Yi-feng Wu & Jun-wei He

  2. Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, Chongqing, 400030, China

    Yi-min Lin

  3. School of Information Technology, Jiangxi University of Finance and Economics, Nanchang, 330013, China

    Zhong-wei He

  4. Pharmacy Department, Lushan Rehabilitation and Rehabilitation Center, PLA Joint Logistics Support Force, Jiujiang, 332000, China

    Ting-fang Zhang

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  1. Li Yang
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Correspondence to Jun-wei He.

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Yang, L., Lin, Ym., He, Zw. et al. Hostaflavanol A, a new anti-inflammatory and antioxidant activities flavanol from the flowers of Hosta plantaginea. Med Chem Res 29, 426–430 (2020). https://doi.org/10.1007/s00044-019-02491-6

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