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The (pro)renin receptors

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Abstract

Two (pro)renin receptors have been characterized so far, the mannose-6-phosphate receptor (M6P-R) and a specific receptor called (P)RR for (pro)renin receptor. Each receptor controls a different aspect of renin and prorenin metabolism. The M6P-R is a clearance receptor, whereas (P)RR mediates their cellular effects by activating intracellular signaling and up-regulating gene expression. Moreover, binding to (P)RR increases renin enzymatic activity and fully activates prorenin, the inactive proenzyme form of renin. Experimental models suggest that increased (P)RR synthesis and/or activation may be relevant to diseases, especially to high blood pressure, to cardiac fibrosis associated with hypertension, and to diabetic nephropathy.

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Authors and Affiliations

  1. Institut de la Santé et de la Recherche Médicale (INSERM), Unit 833, Paris, France

    Geneviève Nguyen & Aurélie Contrepas

  2. Collège de France, 11 place Marcelin Berthelot, 75005, Paris, France

    Geneviève Nguyen & Aurélie Contrepas

Authors
  1. Geneviève Nguyen
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  2. Aurélie Contrepas
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Correspondence to Geneviève Nguyen.

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Nguyen, G., Contrepas, A. The (pro)renin receptors. J Mol Med 86, 643–646 (2008). https://doi.org/10.1007/s00109-008-0319-1

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  • DOI: https://doi.org/10.1007/s00109-008-0319-1

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