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Central nervous system toxicity following topical skin application of lidocaine

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References

  1. Shand DG (1984) Alpha 1-acid glycoprotein and plasma lidocaine binding. Clin Pharmacokinet 9:27–31

    PubMed  Google Scholar 

  2. Wojcicki J, Kozlowsky K, Drozdzik M, Wojcicki M (2002) Lidocaine elimination in patients with liver cirrhosis. Acta Pol Pharm 59(4):321–324

    CAS  PubMed  Google Scholar 

  3. Testa R, Campo N, Caglieris S, Risso D, Alvarez S, Arzani L et al (1998) Lidocaine elimination and monoethylglycinexylidide formation in patients with chronic hepatitis or cirrhosis. Hepatogastroenterology 45(19):154–159

    CAS  PubMed  Google Scholar 

  4. McKindley DS, Boulet J, Sachdeva K, Wang P, Chichester C (2002) Endotoxic shock alters the pharmacokinetics of lidocaine and monoethylglycinexylidide. Shock 17(3):199–204

    Article  PubMed  Google Scholar 

  5. Collinsworth KA, Strong JM, Atkinson AJ Jr, Winkle RA, Perlroth F, Harrison DC (1975) Pharmacokinetics and metabolism of lidocaine in patients with renal failure. Clin Pharmacol Ther 18(1):59–64

    CAS  PubMed  Google Scholar 

  6. Lili C, Shibata N, Yoshikawa Y, Takada K (2003) Effect of glycerol-induced acute renal failure on the pharmacokinetics of lidocaine after transdermal application in rats. Biol Pharm Bull 26(8):1150–1154

    Article  PubMed  Google Scholar 

  7. du Souich P, Saunier C, Hartemann D, Allam M (1992) Effect of acute and chronic moderate hypoxia on the kinetics of lidocaine and its metabolites and on regional blood flow. Pulm Pharmacol Ther 5(1):9–16

    Article  Google Scholar 

  8. Pardridge WM, Sakiyama R, Fierer G (1984) Blood-brain barrier transport and brain sequestration of propranolol and lidocaine. Am J Physiol 247(3):R582–588

    CAS  PubMed  Google Scholar 

  9. Laurikainen E, Marttila R, Lindberg R, Kanto J (1983) Penetration of lidocaine and its active desethylated metabolite into cerebrospinal fluid in man. Eur J Clin Pharmacol 25(5):639–641

    CAS  PubMed  Google Scholar 

  10. Tsai PS, Buerkle H, Huang LT, Lee TC, Yang LC, Lee JH (1998) Lidocaine concentrations in plasma and cerebrospinal fluid after systemic bolus administration in humans. Anesth Analg 87(3):601–604

    Article  CAS  PubMed  Google Scholar 

  11. Parfitt K (ed) (1999) Martindale, the complete drug reference, 32nd edn. Pharmaceutical Press, London

    Google Scholar 

  12. Elad S, Cohen G, Zylber-Katz E, Findler M, Galili D, Garfunkel AA et al (1999) Systemic absorption of lidocaine after topical application for the treatment of oral mucositis in bone marrow transplantation patients. J Oral Pathol Med 28(4):170–172

    CAS  PubMed  Google Scholar 

  13. Wu FL, Razzaghi A, Souney PF (1993) Seizure after lidocaine for bronchoscopy: case report and review of the use of lidocaine in airway anaesthesia. Pharmacotherapy 13(1):72–78

    CAS  PubMed  Google Scholar 

  14. Denaro CP, Benowitz NL (1989) Poisoning due to class 1B antiarrhythmic drugs. Lignocaine, mexiletine and tocainide. Med Toxicol Adverse Exp 4(6):412–428

    CAS  Google Scholar 

  15. Zdziarsky P (2001) Hoigne syndrome as an acute non-allergic reaction to different drugs: case reports. Pol Merkuriusz Lek 10(60):453–455

    PubMed  Google Scholar 

  16. Ameer B, Burlingame MB, Harman EM (1989) Systemic absorption of lidocaine in elderly and young adults undergoing bronchoscopy. Pharmacotherapy 9(2):74–81

    CAS  PubMed  Google Scholar 

  17. Smith M, Wolfram W, Rose R (1992) Toxicity—seizures in an infant caused by (or related to) oral viscous lidocaine use. J Emerg Med 10(5):587–590

    Article  CAS  PubMed  Google Scholar 

  18. Mofenson HC, Caraccio TR, Miller H, Greensher J (1983) Lidocaine toxicity from topical mucosal application. With a review of the clinical pharmacology of Lidocaine. Clin Pediatr 22(3):190–192

    CAS  Google Scholar 

  19. Mehra P, Caiazzo A, Maloney P (1998) Lidocaine toxicity. Anesth Prog 45(1):38–41

    CAS  PubMed  Google Scholar 

  20. Sharma SC, Rama PR, Miller GL, Coccio EB, Coulter LJ (1996) Systemic absorption and toxicity from topically administered lidocaine during transesophageal echocardiography. J Am Soc Echocardiogr 9(5):710–711

    CAS  PubMed  Google Scholar 

  21. Rincon E, Baker RL, Iglesias AJ, Duarte AM (2000) CNS toxicity after topical application of EMLA cream on a toddler with molluscum contagiosum. Pediatr Emerg Care 16(4):252–254

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Medicine J, Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Weizmann street, Tel Aviv, 64239, Israel

    Tal Brosh-Nissimov, Merav Ingbir, Iris Weintal, Mordechai Fried & Reuven Porat

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  1. Tal Brosh-Nissimov
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  2. Merav Ingbir
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  3. Iris Weintal
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  4. Mordechai Fried
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  5. Reuven Porat
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Correspondence to Tal Brosh-Nissimov.

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Brosh-Nissimov, T., Ingbir, M., Weintal, I. et al. Central nervous system toxicity following topical skin application of lidocaine. Eur J Clin Pharmacol 60, 683–684 (2004). https://doi.org/10.1007/s00228-004-0814-4

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  • DOI: https://doi.org/10.1007/s00228-004-0814-4

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