Abstract
While originally cloned from the prostate in 2001, transient receptor potential, melastatin member 8 (TRPM8) has since been identified as the cold/menthol receptor in the peripheral nervous system. This discovery has led to hundreds of studies regarding the role of this channel in pain and thermosensation phenomena, while relegating TRPM8 involvement in cancer to a secondary role. Despite these findings, there is growing evidence that TRPM8 should be carefully studied within the frame of carcinogenesis, especially in the prostate, where it is highly expressed and where many teams have confirmed variations in its expression during cancer progression. Its regulation by physiological factors, such as PSA and androgens, has proved that TRPM8 can exhibit an activity beyond that of a cold receptor, thus explaining how the channel can be activated in organs not exposed to temperature variations. With this review, we aim to provide a brief overview of the current knowledge regarding the complex roles of TRPM8 in prostate carcinogenesis and to show that this research path still represents a “hot” topic with potential clinical applications in the short term.
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Our work was supported by funds from INSERM, University Lille Nord de France, Ministère de l’Education Nationale, LabEx ICST, Ligue Contre le Cancer, Fondation ARC pour la recherche sur le cancer (PJA 20141202010), Agence Nationale pour la Recherche, the Region Hauts de France, SIRIC ONCOLille, Canceropole Nord Ouest, Association pour la Recherche sur les Tumeurs de la Prostate, and the Institut National du Cancer (INCa-PLBIO14-213).
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L. N., G. G., N. P., D. G., and L. L. wrote the paper.
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Noyer, L., Grolez, G.P., Prevarskaya, N. et al. TRPM8 and prostate: a cold case?. Pflugers Arch - Eur J Physiol 470, 1419–1429 (2018). https://doi.org/10.1007/s00424-018-2169-1
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DOI: https://doi.org/10.1007/s00424-018-2169-1