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In vitro effects of resveratrol on Trichinella spiralis

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Abstract

Resveratrol, a natural phytoalexin found mainly in grapes, possesses antibacterial, antifungal, and antiviral properties. However, there is no information about its effects on helminths such as Trichinella sp. In the present study, we investigated the effects of resveratrol on the viability of Trichinella spiralis life stages in vitro. Adult forms, newborn larvae (NBL), and muscle larvae (ML) were incubated with resveratrol at concentrations varying from 12.5 to 200 μg/ml. Resveratrol showed significant anthelmintic activity against NBL and adult forms of Trichinella, but not against ML. Our results suggest that resveratrol may be useful as a therapeutic agent to treat trichinellosis in early stages and warrant its further assessment in animal models of disease.

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Acknowledgments

We thank Dr. Mustafa Delibas, Department of Urology, Izmir, and Dr. Suat Seren, Chest Diseases & Thoracic Surgery Training Hospital, Izmir, Turkey, for statistical analysis.

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Authors and Affiliations

  1. Department of Parasitology, Faculty of Medicine, Dokuz Eylul University, Inciraltı, Izmir, 35340, Turkey

    Soykan Ozkoc, Sema Tuncay, Songul Bayram Delibas & Ciler Akisu

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  1. Soykan Ozkoc
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  2. Sema Tuncay
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  3. Songul Bayram Delibas
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  4. Ciler Akisu
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Correspondence to Soykan Ozkoc.

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Ozkoc, S., Tuncay, S., Delibas, S.B. et al. In vitro effects of resveratrol on Trichinella spiralis . Parasitol Res 105, 1139–1143 (2009). https://doi.org/10.1007/s00436-009-1533-7

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  • DOI: https://doi.org/10.1007/s00436-009-1533-7

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