Abstract
The protein tyrosine phosphatase interacting protein 51 (PTPIP51) is thought to regulate crucial cellular functions such as mitosis, apoptosis, migration, differentiation and communication between organelles as a scaffold protein. These diverse functions are modulated by the tyrosine/serine phosphorylation status of PTPIP51. This review interconnects the insights obtained about the action of PTPIP51 in mitogen-activated protein kinase signaling, nuclear factor kB signaling, calcium homeostasis and chromosomal segregation and identifies important signaling hubs. The interference of PTPIP51 in such multiprotein complexes and their PTPIP51-modulated cross-talk makes PTPIP51 an ideal target for novel drugs such as the small molecule LDC-3.
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This paper is dedicated to Prof. Dr. Drs. mult. h.c. Andreas Oksche on the occasion of his 90th birthday—still inspiring, encouraging and supporting young scientists.
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Brobeil, A., Dietel, E., Gattenlöhner, S. et al. Orchestrating cellular signaling pathways—the cellular “conductor” protein tyrosine phosphatase interacting protein 51 (PTPIP51). Cell Tissue Res 368, 411–423 (2017). https://doi.org/10.1007/s00441-016-2508-5
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DOI: https://doi.org/10.1007/s00441-016-2508-5