Abstract
Vesicular trafficking between endoplasmic reticulum and Golgi plays a major role in the growth and proliferation of breast cancer cells. Various proteins regulate this ER-Golgi kinetics; however, their potential as therapeutic targets in breast cancer has not been much evaluated. In the present review, we try to shed light on the implication of vesicular trafficking–related proteins like Rab family of proteins, in the pathogenesis of breast cancer via promoting cancer cell proliferation and invasion. The literature for this review was mainly searched in PubMed during the years 2014 to 2018 by using the keywords, ‘breast cancer’, ‘breast cancer and its current treatments’, ‘breast cancer and vesicular trafficking’, ‘Rab family proteins in breast cancer’, etc. Targeting proteins involved in vesicular transport like Rab GTPases, the neural precursor cell–expressed developmentally downregulated protein 9 (NEDD9), runt-related transcription factor 2 (RUNX2), human rhomboid family-1 (RHBDF1), monocarboxylate transporter 4, etc., would aid in designing improved therapeutics for the treatment of breast cancer.
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References
Barnes GL, Hebert KE, Kamal M, Javed A, Einhorn TA, Lian JB, Stein GS, Gerstenfeld LC (2004) Fidelity of Runx2 activity in breast cancer cells is required for the generation of metastases-associated osteolytic disease. Cancer Res 64(13):4506–4513. https://doi.org/10.1158/0008-5472.CAN-03-3851
Campos A, Salomon C, Bustos R, Díaz J, Martínez S, Silva V, Reyes C, Díaz-Valdivia N, Varas-Godoy M, Lobos-González L, Quest AF (2018) Caveolin-1-containing extracellular vesicles transport adhesion proteins and promote malignancy in breast cancer cell lines. Nanomedicine 13(20):2597–2609. https://doi.org/10.2217/nnm-2018-0094
Cheng KW, Lahad JP, Kuo WL, Lapuk A, Yamada K, Auersperg N, Liu J, Smith-McCune K, Lu KH, Fishman D, Gray JW (2004) The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers. Nat Med 10(11):1251. https://doi.org/10.1038/nm1125
Chevalier C, Roche S, Bénistant C (2016) Vesicular trafficking regulators are new players in breast cancer progression: role of TOM1L1 in ERBB2-dependent invasion. Mol Cell Oncol 3(4):e1182241. https://doi.org/10.1080/23723556.2016.1182241
Claesson-Welsh L, Welsh M (2013) VEGFA and tumour angiogenesis. J Intern Med 273(2):114–127. https://doi.org/10.1111/joim.12019
Didier DK, Schiffenbauer J, Woulfe SL, Zacheis M, Schwartz BD (1988) Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box. Proc Natl Acad Sci 85(19):7322–7326. https://doi.org/10.1073/pnas.85.19.7322
Dong Y, Pan Q, Jiang L, Chen Z, Zhang F, Liu Y, Xing H, Shi M, Li J, Li X, Zhu Y (2014) Tumor endothelial expression of P-glycoprotein upon microvesicular transfer of TrpC5 derived from adriamycin-resistant breast cancer cells. Biochem Biophys Res Commun 446(1):85–90. https://doi.org/10.1016/j.bbrc.2014.02.076
Finn RS (2008) Targeting Src in breast cancer. Ann Oncol 19(8):1379–1386. https://doi.org/10.1093/annonc/mdn291
Gallagher SM, Castorino JJ, Wang D, Philp NJ (2007) Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membrane in the metastatic breast cancer cell line MDA-MB-231. Cancer Res 67(9):4182–4189 https://cancerres.aacrjournals.org/content/about-us
Hashimoto S, Onodera Y, Hashimoto A, Tanaka M, Hamaguchi M, Yamada A, Sabe H (2004) Requirement for Arf6 in breast cancer invasive activities. Proc Natl Acad Sci 101(17):6647–6652. https://doi.org/10.1073/pnas.0401753101
Hendrix A, Maynard D, Pauwels P, Braems G, Denys H, Van den Broecke R, Lambert J, Van Belle S, Cocquyt V, Gespach C, Bracke M (2010) Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis. JNCI: J Natl Cancer Inst 102(12):866–880. https://doi.org/10.1093/jnci/djq153
Hortobagyi GN, de la Garza SJ, Pritchard K, Amadori D, Haidinger R, Hudis CA, Khaled H, Liu MC, Martin M, Namer M, O'Shaughnessy JA (2005) The global breast cancer burden: variations in epidemiology and survival. Clin Breast Cancer 6(5):391–401. https://doi.org/10.3816/CBC.2005.n.043
Howley BV, Link LA, Grelet S, El-Sabban M, Howe PH (2018) A CREB3-regulated ER–Golgi trafficking signature promotes metastatic progression in breast cancer. Oncogene 37(10):1308–1325. https://doi.org/10.1038/s41388-017-0023-0
Jacob A, Jing J, Lee J, Schedin P, Gilbert SM, Peden AA, Junutula JR, Prekeris R (2013) Rab40b regulates trafficking of MMP2 and MMP9 during invadopodia formation and invasion of breast cancer cells. J Cell Sci 126(20):4647–4658. https://doi.org/10.1242/jcs.126573
Javed A, Barnes GL, Pratap J, Antkowiak T, Gerstenfeld LC, Van Wijnen AJ, Stein JL, Lian JB, Stein GS (2005) Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo. Proc Natl Acad Sci 102(5):1454–1459. https://doi.org/10.1073/pnas.0409121102
Johansson S, Svensson H, Larsson LG, Denekamp J (2000) Brachial plexopathy after postoperative radiotherapy of breast cancer patients: a long-term follow-up. Acta Oncol 39(3):373–382. https://doi.org/10.1080/028418600750013140
Johnson FM, Gallick GE (2007) SRC family nonreceptor tyrosine kinases as molecular targets for cancer therapy. Anticancer Agents Med Chem (Formerly Current Medicinal Chemistry-Anti-Cancer Agents) 7(6):651–659. https://doi.org/10.2174/187152007784111278
Kajiho H, Kajiho Y, Frittoli E, Confalonieri S, Bertalot G, Viale G, Di Fiore PP, Oldani A, Garre M, Beznoussenko GV, Palamidessi A (2016) RAB2A controls MT1-MMP endocytic and E-cadherin polarized Golgi trafficking to promote invasive breast cancer programs. EMBO Rep 17(7):1061–1080. https://doi.org/10.15252/embr.201642032
Kozyulina PY, Loskutov YV, Kozyreva VK, Rajulapati A, Ice RJ, Jones BC, Pugacheva EN (2015) Prometastatic NEDD9 regulates individual cell migration via caveolin-1–dependent trafficking of Integrins. Mol Cancer Res 13(3):423–438. https://doi.org/10.1158/1541-7786.MCR-14-0353
Kurt S, Can G (2018) Reflexology in the management of chemotherapy induced peripheral neuropathy: a pilot randomized controlled trial. Eur J Oncol Nurs 32:12–19. https://doi.org/10.1016/j.ejon.2017.11.001
Kurten RC, Cadena DL, Gill GN (1996) Enhanced degradation of EGF receptors by a sorting nexin, SNX1. Science 272(5264):1008–1010. https://doi.org/10.1126/science.272.5264.1008
Kurten RC, Eddington AD, Chowdhury P, Smith RD, Davidson AD, Shank BB (2001) Self-assembly and binding of a sorting nexin to sorting endosomes. J Cell Sci 114(9):1743–1756. 11309204
Li J, Bai TR, Gao S, Zhou Z, Peng XM, Zhang LS, Dou DL, Zhang ZS, Li LY (2018) Human rhomboid family-1 modulates clathrin coated vesicle-dependent pro-transforming growth factor α membrane trafficking to promote breast cancer progression. EBioMedicine 36:229–240. https://doi.org/10.1016/j.ebiom.2018.09.038
Loskutov YV, Kozyulina PY, Kozyreva VK, Ice RJ, Jones BC, Roston TJ, Smolkin MB, Ivanov AV, Wysolmerski RB, Pugacheva EN (2015) NEDD9/Arf6-dependent endocytic trafficking of matrix metalloproteinase 14: a novel mechanism for blocking mesenchymal cell invasion and metastasis of breast cancer. Oncogene 34(28):3662–3675. https://doi.org/10.1038/onc.2014.297
Lovett DH, Cheng S, Cape L, Pollock AS, Mertens PR (2010) YB-1 alters MT1-MMP trafficking and stimulates MCF-7 breast tumor invasion and metastasis. Biochem Biophys Res Commun 398(3):482–488. https://doi.org/10.1016/j.bbrc.2010.06.104
Ma X, Chen Z, Hua D, He D, Wang L, Zhang P, Wang J, Cai Y, Gao C, Zhang X, Zhang F (2014) Essential role for TrpC5-containing extracellular vesicles in breast cancer with chemotherapeutic resistance. Proc Natl Acad Sci 111(17):6389–6394. https://doi.org/10.1073/pnas.1400272111
Piazza TM, Lu JC, Carver KC, Schuler LA (2009) SRC family kinases accelerate prolactin receptor internalization, modulating trafficking and signaling in breast cancer cells. Mol Endocrinol 23(2):202–212. https://doi.org/10.1210/me.2008-0341
Tao Z, Shi A, Lu C, Song T, Zhang Z, Zhao J (2015) Breast cancer: epidemiology and etiology. Cell Biochem Biophys 72(2):333–338. https://doi.org/10.1007/s12013-014-0459-6
Wang T, Gilkes DM, Takano N, Xiang L, Luo W, Bishop CJ, Chaturvedi P, Green JJ, Semenza GL (2014) Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis. Proc Natl Acad Sci 111(31):E3234–E3242. https://doi.org/10.1073/pnas.1410041111
World Health Organization (WHO). Breast cancer: Early diagnosis and screening. https://www.who.int/cancer/detection/breastcancer/en/, Accessed June 2019. World Health Organization and Health Action International (WHO-HAI). 2008. Introduction. In Measuring medicine prices, availability, affordability, and price components. 2nd ed. Chapter 1, p. 1. No.WHO/PSM/PAR/ 2008.3. Geneva: World Health Organization (WHO). Worby CA, Dixon JE (2002) Sorting out the cellular functions of sorting nexins Nature Reviews Molecular Cell Biology 3:919 doi:https://doi.org/10.1038/nrm974
Wright PK, May FE, Darby S, Saif R, Lennard TW, Westley BR (2009) Estrogen regulates vesicle trafficking gene expression in EFF-3, EFM-19 and MCF-7 breast cancer cells. Int J Clin Exp Pathol 2(5):463–475. 19294005
Wright PK, Jones SB, Ardern N, Ward R, Clarke RB, Sotgia F, Lisanti MP, Landberg G, Lamb R (2014) 17β-estradiol regulates giant vesicle formation via estrogen receptor-alpha in humean breast cancer cells. Oncotarget 5(10):3055. https://doi.org/10.18632/oncotarget.1824
Funding
This study was financially support by the Indian Council of Medical Research (ICMR), Govt. of India in the form of fellowship to Mohd Mughees under Senior Research Fellowship (SRF)/Research Associateship (RA) scheme [45/25/2018-NAN/BMS].
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Mughees, M., Chugh, H. & Wajid, S. Vesicular trafficking–related proteins as the potential therapeutic target for breast cancer. Protoplasma 257, 345–352 (2020). https://doi.org/10.1007/s00709-019-01462-3
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DOI: https://doi.org/10.1007/s00709-019-01462-3