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Epithelioid glioblastoma arising from pleomorphic xanthoastrocytoma with the BRAF V600E mutation

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Abstract

Pleomorphic xanthoastrocytoma (PXA) is classified by the World Health Organization as a grade II astrocytic tumor with relatively favorable prognosis among gliomas. A valine-to-glutamic acid substitution at position 600 of the serine/threonine-protein kinase BRAF (BRAF V600E) mutation, which is commonly found in PXA, has recently been detected in approximately 50 % of all epithelioid glioblastoma (GBM) cases. We herein report a case of epithelioid GBM developing at the site of a left temporal PXA 13 years after the treatment of the primary tumor. The BRAF V600E mutation was detected in both tumors. These findings suggest that epithelioid GBM may arise from a PXA with a BRAF V600E mutation.

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Fig. 1
Fig. 2

Abbreviations

BRAF V600E:

A valine-to-glutamic acid substitution at position 600 of the serine/threonine-protein kinase BRAF

EMA:

Epithelial membrane antigen

GFAP:

Glial fibrillary acidic protein

GBM:

Glioblastoma

Gd:

Gadolinium

MRI:

Magnetic resonance imaging

PXA:

Pleomorphic xanthoastrocytoma

WHO:

World Health Organization

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Acknowledgments

The authors are grateful to Erika Komura and Akiko Imamura for help with preparation of the slides and immunohistochemistry.

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Authors and Affiliations

  1. Division of Neuroscience, Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan

    Shingo Tanaka, Mitsutoshi Nakada, Hemragul Sabit, Katsuyoshi Miyashita & Yutaka Hayashi

  2. Department of Human Pathology, Gunma University Graduate School of Medicine, Maebashi, Japan

    Sumihito Nobusawa

  3. Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Satoshi O. Suzuki

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  1. Shingo Tanaka
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  2. Mitsutoshi Nakada
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Correspondence to Mitsutoshi Nakada.

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Tanaka, S., Nakada, M., Nobusawa, S. et al. Epithelioid glioblastoma arising from pleomorphic xanthoastrocytoma with the BRAF V600E mutation. Brain Tumor Pathol 31, 172–176 (2014). https://doi.org/10.1007/s10014-014-0192-2

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  • DOI: https://doi.org/10.1007/s10014-014-0192-2

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