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Frontal assessment battery scores and non-motor symptoms in parkinsonian disorders

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Abstract

Using data from the PRIAMO study, we investigated non-motor symptoms (NMS) versus frontal lobe dysfunction in patients with idiopathic Parkinson disease (PD); 808 patients with PD and 118 with atypical parkinsonisms (AP) were consecutively enrolled at 55 Centers in Italy. Twelve categories of NMS were investigated. Cognitive impairment was defined as a Mini-Mental Status Evaluation score ≤23.8 and frontal lobe dysfunction as a Frontal Assessment Battery (FAB) score ≤13.48. Multivariable logistic regression was used to identify predictor of frontal lobe dysfunction in 524 PD patients, and a generalized linear model was used for each of the six FAB items. Not only the total FAB scores but also the single FAB items were lower in AP versus PD (p ≤ 0.005). Age (OR = 1.05), cognitive impairment (OR = 9.54), lack of cardiovascular symptoms (OR = 3.25), attention or memory problems (OR = 0.59) and treatment with l-DOPA (OR = 5.58) were predictors of frontal lobe dysfunction. MMSE was negatively associated with all FAB items (β ≤ −0.16) and age with all FAB items but prehension behavior (β ≤ −0.01). Previous use of l-DOPA was negatively associated with verbal fluency (β = −0.32) possibly acting as surrogate marker of disease duration. Cognitive impairment is a predictor of frontal lobe dysfunction. Among NMS, lack of attention or memory problems were negatively associated with frontal impairment. Further studies are nonetheless needed to better identify the predictors of frontal impairment in PD patients.

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Acknowledgments

PRIAMO was supported by an educational grant from Boehringer-Ingelheim Italy. We are grateful to MediData (Modena, Italy) for data collection and statistical analysis and to Sara Rizzoli and Lucia Simoni for help in writing the manuscript.

Author information

Authors and Affiliations

  1. Dipartimento di Neuroscienze, Ospedale Misericordia, Via Senese, 171, 58100, Grosseto, Italy

    Roberto Marconi & Lucia Grasso

  2. IRCCS San Camillo Venice and Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy

    Angelo Antonini & Danilo De Gaspari

  3. Neurodegenerative Diseases Centre, University of Salerno and IDC Hermitage-Capodimonte, Naples, Italy

    Paolo Barone & Gabriella Santangelo

  4. Dipartimento di Neurologia e Psichiatria, Sapienza Università di Roma, Rome, Italy

    Carlo Colosimo & Giuseppe Meco

  5. Neurologia, Ospedale Villa Sofia CTO, Palermo, Italy

    Tania P. Avarello

  6. U.O. di Neurologia, Ospedale Regionale, Aosta, Italy

    Edo Bottacchi

  7. Clinica Neurologica, Policlinico Universitario, Monserrato, Cagliari, Italy

    Antonino Cannas

  8. Clinica di Neuroriabilitazione, Ospedale Umberto I, Ancona, Italy

    Maria G. Ceravolo

  9. Neurologia, Ospedale Santa Chiara, Pisa, Italy

    Roberto Ceravolo

  10. Neurologia e Stroke, A.O.R.N. San Giuseppe Moscati, Avellino, Italy

    Giulio Cicarelli

  11. U.O. di Neurologia, Azienda Ospedaliera S.Giovanni di Dio, Agrigento, Italy

    Rosa M. Gaglio

  12. Neurologia, Azienda Ospedaliera S. Elia, Caltanissetta, Italy

    Luisa Giglia

  13. U.O. di Neurologia, Ospedale Guzzardi, Vittoria, Ragusa, Italy

    Francesco Iemolo

  14. Neurologia, Fondazione Poliambulanza, Brescia, Italy

    Michela Manfredi

  15. Clinica Neurologica I, Policlinico Universitario, Catania, Italy

    Alessandra Nicoletti

  16. Neurologia, Ospedale Civile, Vimercate, Milan, Italy

    Massimo Pederzoli

  17. Neurologia, Presidio Ospedaliero Annunziata, Cosenza, Italy

    Alfredo Petrone

  18. Policlinico Tor Vergata, Fondazione Santa Lucia, IRCCS, Rome, Italy

    Antonio Pisani

  19. Ospedale Sant’Andrea, Università La Sapienza, Rome, Italy

    Francesco E. Pontieri

  20. Neurologia Dipartimento Neuroscienze applicate alla clinica, Ospedale Sant’Anna, Ferrara, Italy

    Rocco Quatrale

  21. Clinica Neurologica, Azienda Ospedaliera Universitaria, Florence, Italy

    Silvia Ramat

  22. Neurologia, Ospedale S. Maria Loreto Nuovo, Naples, Italy

    Rossana Scala

  23. Neurofisiopatologia Dipartimento Neuro Orto Traumatologia, Presidio Ospedaliero S. Luca, Vallo della Lucania, Salerno, Italy

    Giampiero Volpe

  24. Neurologia, Ospedale Umberto I, Enna, Italy

    Salvatore Zappulla

  25. Clinica Neurologica, Università Cattolica del Sacro Cuore, Rome, Italy

    Anna Rita Bentivoglio

  26. IRCCS San Raffaele, Rome, Italy

    Fabrizio Stocchi

  27. Neurologia, P.O.F. Ferrari, Casarano, Lecce, Italy

    Giorgio Trianni

  28. U.O. di Neurologia, Ospedale Versilia, Camaiore, Italy

    Paolo Del Dotto

  29. Dipartimento di Neurologia e Psichiatria, Sapienza Università di Roma e Istituto Neuromed, Pozzilli, Isernia, Italy

    Giovanni Fabbrini

  30. Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche Università di Messina, Messina, Italy

    Francesca Morgante & Letterio Morgante

Authors
  1. Roberto Marconi
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  2. Angelo Antonini
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  3. Paolo Barone
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  4. Carlo Colosimo
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  5. Tania P. Avarello
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  6. Edo Bottacchi
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  7. Antonino Cannas
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  8. Maria G. Ceravolo
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  9. Roberto Ceravolo
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  10. Giulio Cicarelli
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  11. Rosa M. Gaglio
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  12. Luisa Giglia
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  13. Francesco Iemolo
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  14. Michela Manfredi
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  15. Giuseppe Meco
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  16. Alessandra Nicoletti
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  17. Massimo Pederzoli
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  18. Alfredo Petrone
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  19. Antonio Pisani
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  20. Francesco E. Pontieri
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  21. Rocco Quatrale
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  22. Silvia Ramat
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  23. Rossana Scala
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  24. Giampiero Volpe
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  25. Salvatore Zappulla
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  26. Anna Rita Bentivoglio
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  27. Fabrizio Stocchi
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  28. Giorgio Trianni
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  29. Paolo Del Dotto
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  30. Danilo De Gaspari
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  31. Lucia Grasso
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  32. Francesca Morgante
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  33. Gabriella Santangelo
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  34. Giovanni Fabbrini
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  35. Letterio Morgante
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Corresponding author

Correspondence to Roberto Marconi.

Additional information

On behalf of the PRIAMO study group.

Appendix: The PRIAMO study group

Appendix: The PRIAMO study group

Steering Committee:

  • Angelo Antonini—IRCCS San Camillo Venice and Parkinson Institute, Istituti Clinici di Perfezionamento, Milano

  • Paolo Barone—Neurodegenerative Diseases Centre, University of Salerno and IDC Hermitage-Capodimonte, Napoli

  • Carlo Colosimo—Sapienza Università di Roma

  • Roberto Marconi—Ospedale della Misericordia, Grosseto

  • Letterio Morgante—Università di Messina, Italy

Participating centers:

  • Benincasa D—Ospedale Sant’Andrea, Sapienza Università di Roma

  • Sensi M—Ospedale Sant’Anna, Ferrara

  • Braga M—Ospedale Civile, Vimercate

  • Capecci M—Ospedale Umberto I, Ancona

  • Caravona N—Sapienza Università di Roma

  • D’Asta G—PO Guzzardi, Vittoria

  • De Falco FA—Ospedale S Maria Loreto Nuovo, Napoli

  • Pezzoli G—Istituti Clinici di Perfezionamento, Milano

  • Di Giovanni M—Ospedale Regionale, Aosta

  • Floris G—Clinica Neurologica, Policlinico Universitario, Monserrato,Cagliari

  • Gallerini S—Ospedale della Misericordia, Grosseto

  • Gurgone G—Azienda Ospedaliera S. Giovanni di Dio, Agrigento

  • Frosini D—Ospedale Santa Chiara, Pisa

  • Meoni S—Clinica Neurologica I, Università di Firenze

  • Savica R—Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina

  • Moschella V—Policlinico Tor Vergata, Roma

  • Pepe F—Fondazione Poliambulanza, Brescia

  • Petretta V—AORN San Giuseppe Moscati, Avellino

  • Randisi MG—Azienda Ospedaliera S Elia, Caltanissetta

  • Romeno M—Ospedale Villa Sofia CTO, Palermo

  • Picillo M—Università Federico II, Napoli

  • Sorbello V—Policlinico Universitario, Catania

  • Tiple D—Sapienza Università di Roma

  • Guidubaldi A—Università Cattolica S Cuore, Roma

  • Muoio R—IRCCS San Raffaele, Roma

  • Toni V—PO F Ferrari, Casarano

  • Logi C—Ospedale Versilia, Camaiore

  • Bartalini S, Ulivelli M—Policlinico Le Scotte, Siena

  • Perini M, Lanfranchi S—Ospedale S Antonio Abate, Gallarate

  • Griffini S, Troianiello B—Istituto Clinico Città di Brescia

  • Baratti M, Amidei S—Ospedale Ramazzini, Carpi

  • Consoli D, Iellamo M—Ospedale G Iazzolino, Vibo Valentia

  • Cuomo T—Ospedale Civile Umberto I, Nocera Inferiore

  • Scaglioni A, Medici D—Ospedale di Vaio, Fidenza

  • Abbruzzese G, Di Brigida G—Centro Parkinson, Dipartimento di Neuroscienze, Oftalmologia e Genetica, Università degli Studi di Genova, Genova

  • Cocco GA, Agnetti V—Università degli Studi di Sassari, Sassari

  • Cossu G, Deriu M—Azienda Ospedaliera G Brotzu, Cagliari

  • Abrignani M, Modica C—Ospedale San Biagio di Marsala, Marsala

  • Albani G, Pradotto L—Divisione di Neurologia e Neuroriabilitazione, Istituto Auxologico Italiano, IRCCS Piancavallo (Verbania)

  • Martinelli P, Scaglione C—Università di Bologna, Bologna

  • Mucchiut M, Zanini S—Policlinico Universitario, Udine

  • Pennisi F—Ospedale di Castelvetrano, Castelvetrano, Trapani

  • Soliveri P, Albanese A—Istituto Nazionale Neurologico C Besta, Milano

  • Bartolomei L, L’Erario R—Ospedale Civile San Bortolo, Vicenza

  • Capus L, Ferigo L—Ospedale di Gattinara, Trieste

  • Marano R, Nastasi V—Azienda Ospedaliera Papardo, Messina

  • Luciano R, Maiello L—Ospedale Monaldi, Napoli

  • Simone P, Fogli D—Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo

  • Lopiano L, Pesare M—ASO Molinette, Torino

  • Nordera G, Pilleri E—Casa di Cura Villa Margherita, Arcugnano

  • Scaravilli T—Azienda Ospedaliera Padova, Padova

  • Giaccaglini E, Alesi C—Ospedale Civile, Jesi, Italy

Sponsorship:

  • Tania Corbetta, Arina Dumitriu, Boehringer Ingelheim, Milano, Italy

Project Management, Statistical Analyses and Data Management:

  • Simona Sgarbi, project leader, MediData Studi e Ricerche, Modena

  • Andrea Rapisarda, clinical project manager, MediData Studi e Ricerche, Modena

  • Sara Rizzoli, Lucia Simoni, statisticians, MediData Studi e Ricerche, Modena

  • Luca Zanoli, clinical data manager, MediData Studi e Ricerche, Modena

  • Alessandra Manfredi, clinical operation specialist, MediData Studi e Ricerche, Modena, Italy

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Marconi, R., Antonini, A., Barone, P. et al. Frontal assessment battery scores and non-motor symptoms in parkinsonian disorders. Neurol Sci 33, 585–593 (2012). https://doi.org/10.1007/s10072-011-0807-x

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  • DOI: https://doi.org/10.1007/s10072-011-0807-x

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