Abstract
Cadmium (Cd) is an environmental contaminant known to exert significant neurotoxic effects on both humans and experimental animals. The aim of this study was to shed more light on the effects of gestational (in utero) and lactational maternal exposure to Cd (50 ppm of Cd as Cd-chloride in the drinking water) on crucial brain enzyme activities in important rat offspring brain regions (frontal cortex, hippocampus, hypothalamus, pons and cerebellum). Our study provides a brain region-specific view of the changes in the activities of three crucial brain enzymes as a result of the developmental neurotoxicity of Cd. Maternal exposure to Cd during both gestation and lactation results into significant changes in the activities of acetylcholinesterase and Na+,K+-ATPase in the frontal cortex and the cerebellum of the offspring rats, as well as in a significant increase in the hippocampal Mg2+-ATPase activity. These brain-region-specific findings underline the need for further research in the field of Cd-induced developmental neurotoxicity. Deeper understanding of the mechanisms underlying the neurodevelopmental deficits taking place due to in utero and early age exposure to Cd could shed more light on the causes of its well-established cognitive implications.
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This study was funded by the National and Kapodistrian University of Athens. The authors wish to acknowledge their appreciation to Dr. Hussam Al-Humadi and Mr. Konstantinos M. Zissis for their assistance.
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Stolakis, V., Tsakiris, S., Kalafatakis, K. et al. Developmental neurotoxicity of cadmium on enzyme activities of crucial offspring rat brain regions. Biometals 26, 1013–1021 (2013). https://doi.org/10.1007/s10534-013-9678-3
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DOI: https://doi.org/10.1007/s10534-013-9678-3